PMID- 23725859
OWN - NLM
STAT- MEDLINE
DCOM- 20140613
LR  - 20220330
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 107
IP  - 3
DP  - 2013 Jun
TI  - Volumetric modulated arc therapy with flattening filter free (FFF) beams for 
      stereotactic body radiation therapy (SBRT) in patients with medically inoperable 
      early stage non small cell lung cancer (NSCLC).
PG  - 414-8
LID - S0167-8140(13)00191-6 [pii]
LID - 10.1016/j.radonc.2013.04.016 [doi]
AB  - PURPOSE: To assess the impact of volumetric modulated arc therapy (VMAT) with 
      flattening filter free (FFF) beams for stereotactic body radiotherapy (SBRT) in 
      inoperable stage I NSCLC. Current data were compared against a cohort of patients 
      previously treated with advanced conformal techniques (3DCRT) based on conformal 
      arcs. METHODS AND MATERIALS: From July 2006 to December 2011 132 patients 
      underwent SBRT, 86 by 3DCRT with flattened beams (FF), while the last 46 with 
      VMAT RapidArc and unflattened beams (FFF). All patients were treated with 48 Gy 
      in four fractions of 12 Gy each. Patients underwent follow-up. Clinical outcome 
      was evaluated with thoracic and abdominal CT scan and 18FDG-CTPET before and 
      after treatment. RESULTS: Both techniques achieved adequate dose conformity to 
      the target but with a statistically significant reduction of ipsilateral lung 
      doses in RapidArc plans and also of Beam-on-Time (BOT) with FFF mode. The median 
      follow up was 16 months (range 2-24 months). At 1 year, local control rate was 
      100% with FFF beams compared with 92.5% with FF beams (p=0.03). CONCLUSIONS: SBRT 
      with FFF beams permitted us a safe delivery of high dose per fraction in a short 
      treatment time and resulted in an earlier radiological response compared with FF 
      beams.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Navarria, Pierina
AU  - Navarria P
AD  - Radiotherapy and Radiosurgery Department, Humanitas Cancer Center, Istituto 
      Clinico Humanitas, Milan, Italy. piera.navarria@cancercenter.humanitas.it
FAU - Ascolese, Anna Maria
AU  - Ascolese AM
FAU - Mancosu, Pietro
AU  - Mancosu P
FAU - Alongi, Filippo
AU  - Alongi F
FAU - Clerici, Elena
AU  - Clerici E
FAU - Tozzi, Angelo
AU  - Tozzi A
FAU - Iftode, Cristina
AU  - Iftode C
FAU - Reggiori, Giacomo
AU  - Reggiori G
FAU - Tomatis, Stefano
AU  - Tomatis S
FAU - Infante, Maurizio
AU  - Infante M
FAU - Alloisio, Marco
AU  - Alloisio M
FAU - Testori, Alberto
AU  - Testori A
FAU - Fogliata, Antonella
AU  - Fogliata A
FAU - Cozzi, Luca
AU  - Cozzi L
FAU - Morenghi, Emanuela
AU  - Morenghi E
FAU - Scorsetti, Marta
AU  - Scorsetti M
LA  - eng
PT  - Journal Article
DEP - 20130528
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic 
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/mortality/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/diagnostic imaging/mortality/pathology/*surgery
MH  - Male
MH  - Neoplasm Staging
MH  - Radiography
MH  - Radiosurgery/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated/*methods
OTO - NOTNLM
OT  - NSCLC
OT  - SBRT
OT  - Volumetric modulated Arc Therapy
EDAT- 2013/06/04 06:00
MHDA- 2014/06/15 06:00
CRDT- 2013/06/04 06:00
PHST- 2012/10/19 00:00 [received]
PHST- 2013/04/05 00:00 [revised]
PHST- 2013/04/27 00:00 [accepted]
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/06/15 06:00 [medline]
AID - S0167-8140(13)00191-6 [pii]
AID - 10.1016/j.radonc.2013.04.016 [doi]
PST - ppublish
SO  - Radiother Oncol. 2013 Jun;107(3):414-8. doi: 10.1016/j.radonc.2013.04.016. Epub 
      2013 May 28.