PMID- 23726529
OWN - NLM
STAT- MEDLINE
DCOM- 20140911
LR  - 20211203
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 217
IP  - 2-3
DP  - 2014 Mar
TI  - The relationship of blood lead with immunoglobulin E, eosinophils, and asthma 
      among children: NHANES 2005-2006.
PG  - 196-204
LID - S1438-4639(13)00064-3 [pii]
LID - 10.1016/j.ijheh.2013.04.010 [doi]
AB  - Early life lead exposure may alter immune function and predispose a child to 
      develop asthma. In an initial exploration of this hypothesis, we examined the 
      association between blood lead, and serum immunoglobulin E (IgE), eosinophils, 
      and asthma prevalence in a cross-sectional study of 1788 children from the 
      National Health and Nutrition Examination Survey 2005-2006. Geometric mean blood 
      lead, serum IgE, and percent eosinophils were 1.13 mug/dL (95% confidence interval 
      (CI): 1.04, 1.22), 46.3 kU/L (95% CI: 40.3, 53.1), and 2.82 percent (95% CI 2.67, 
      2.98), respectively. Prevalence of asthma, atopic asthma, and atopy were 11.8% 
      (95% CI: 9.5, 14.2), 8.1% (6.2, 9.9), and 44.4% (40.1, 48.7), respectively. 
      Regression models controlled for season, age, sex, race/ethnicity, education, 
      passive smoke exposure, and body mass index. Based on these models, there was an 
      11.1% (95% CI: 5.6, 16.9) increase in IgE and a 4.9% (95% CI: 2.3, 7.6) increase 
      in eosinophils per 1 mug/dL increase in blood lead. In independent stratified 
      analyses, lead was found to increase IgE and eosinophils among non-Hispanic 
      whites, but not other children; and stronger associations were observed among 
      children who lived with a smoker vs. not. Lead was not associated with asthma, 
      atopic asthma, or general atopy. This study provides additional evidence of a 
      cross-sectional association between lead with IgE and new evidence for 
      eosinophils. This may be a mechanism for development of downstream allergic 
      disease. The mechanisms that determine ultimate development of allergic disease 
      are currently unknown, but are the focus of ongoing studies.
CI  - Copyright (c) 2013 Elsevier GmbH. All rights reserved.
FAU - Wells, Ellen M
AU  - Wells EM
AD  - Department of Environmental Health Sciences, Case Western Reserve University 
      School of Medicine, Cleveland, OH, USA; Department of Epidemiology and 
      Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, 
      USA. Electronic address: ellen.wells@case.edu.
FAU - Bonfield, Tracey L
AU  - Bonfield TL
AD  - Department of Pediatrics, Case Western Reserve University School of Medicine, 
      Cleveland, OH, USA.
FAU - Dearborn, Dorr G
AU  - Dearborn DG
AD  - Department of Environmental Health Sciences, Case Western Reserve University 
      School of Medicine, Cleveland, OH, USA.
FAU - Jackson, Leila W
AU  - Jackson LW
AD  - Department of Environmental Health Sciences, Case Western Reserve University 
      School of Medicine, Cleveland, OH, USA; Department of Epidemiology and 
      Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, 
      USA; Applied Public Health Research and Evaluation, Cleveland, OH, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130509
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Tobacco Smoke Pollution)
RN  - 2P299V784P (Lead)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Asthma/epidemiology/etiology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Eosinophils/*metabolism
MH  - Ethnicity
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/epidemiology/etiology
MH  - Immunoglobulin E/*blood
MH  - *Lead/blood/immunology
MH  - Male
MH  - Nutrition Surveys
MH  - Prevalence
MH  - Tobacco Smoke Pollution
OTO - NOTNLM
OT  - Asthma
OT  - Child
OT  - Eosinophils
OT  - Immunoglobulin E
OT  - Lead
OT  - NHANES
OT  - National Health and Nutrition Examination Survey
EDAT- 2013/06/04 06:00
MHDA- 2014/09/12 06:00
CRDT- 2013/06/04 06:00
PHST- 2012/05/21 00:00 [received]
PHST- 2013/03/30 00:00 [revised]
PHST- 2013/04/22 00:00 [accepted]
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/09/12 06:00 [medline]
AID - S1438-4639(13)00064-3 [pii]
AID - 10.1016/j.ijheh.2013.04.010 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2014 Mar;217(2-3):196-204. doi: 
      10.1016/j.ijheh.2013.04.010. Epub 2013 May 9.