PMID- 23726593
OWN - NLM
STAT- MEDLINE
DCOM- 20131230
LR  - 20130603
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 45
IP  - 4
DP  - 2013 May
TI  - Donor factors predictive for poor outcomes of living donor kidney 
      transplantation.
PG  - 1445-8
LID - S0041-1345(12)01380-2 [pii]
LID - 10.1016/j.transproceed.2012.11.015 [doi]
AB  - INTRODUCTION: The aim of this study was to explore donor risk factors that 
      predict the poor outcomes after living donor kidney transplantation. METHODS: We 
      retrospectively analyzed our 219 living donor kidney transplantations collecting 
      donor age and gender, graft glomeular filtration rate (GFR), human leukocyte 
      antigen (HLA) typing, recipient age and gender, acute rejection episodes chronic 
      rejection, and 1-year serum creatinine level. Patient and graft survivals were 
      calculated using the Kaplan-Meier analysis. Independent donor risk factors 
      affecting graft survival and 1-year serum creatinine level were analyzed using 
      Cox regression and logistic regression. RESULTS: One-, 3-, 5-year patient and 
      graft survivals were 98.6%, 98.1%, and 97.4% and 97.7%, 95.0%, and 92.2%, 
      respectively. Acute rejection rate was 12.8%, and chronic rejection, 4.1%. If 
      donor age was over 50 years, there were significantly increased incidences of 
      acute and chronic rejection (chi(2) were 5.385 and 5.039; P < .05). Univariate 
      analysis showed donor age > 50 years, graft GFR < 35 mL/min, female to male, HLA 
      mismatch > 3 loci to be risk factors for an abnormal 1-year serum creatinine. 
      Logistic multivariate regression revealed donor age > 50 years, female to male, 
      and graft GFR before transplant < 35 mL/min to be independent risk factors for an 
      abnormal 1-year serum creatinine level (odds ratio values 5.928, 2.489, and 
      6.993, respectively; P < .05). Cox multivariate regression demonstrated that 
      graft GFR before transplant < 35 mL/min was an independent risk factor for 
      long-term graft survival (relative risk value = 6.984; P = .004). CONCLUSION: 
      Older donor, female to male, and insufficient graft GFR before transplantation 
      are predictive factors for poor outcomes of living donor kidney transplantations.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Chen, G D
AU  - Chen GD
AD  - Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, 
      Sun Yat-sen University, Guangzhou, China.
FAU - Gu, J L
AU  - Gu JL
FAU - Zhang, X D
AU  - Zhang XD
FAU - Qiu, J
AU  - Qiu J
FAU - Wang, C X
AU  - Wang CX
FAU - Chen, L Z
AU  - Chen LZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Creatinine/blood
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Graft Survival
MH  - Humans
MH  - *Kidney Transplantation
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - *Tissue Donors
EDAT- 2013/06/04 06:00
MHDA- 2014/01/01 06:00
CRDT- 2013/06/04 06:00
PHST- 2012/11/07 00:00 [received]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - S0041-1345(12)01380-2 [pii]
AID - 10.1016/j.transproceed.2012.11.015 [doi]
PST - ppublish
SO  - Transplant Proc. 2013 May;45(4):1445-8. doi: 10.1016/j.transproceed.2012.11.015.