PMID- 23726960
OWN - NLM
STAT- MEDLINE
DCOM- 20131127
LR  - 20211203
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 248
DP  - 2013 Oct
TI  - Intermittent hypoxia training after C2 hemisection modifies the expression of 
      PTEN and mTOR.
PG  - 45-52
LID - S0014-4886(13)00159-3 [pii]
LID - 10.1016/j.expneurol.2013.05.013 [doi]
AB  - In this study, we examined modulations in phosphatase and tensin homolog (PTEN) 
      and mammalian target of rapamycin (mTOR) protein expression after a lateral C2 
      hemisection and subsequent intermittent hypoxia (IH) exposure and training, which 
      initiates respiratory motor plasticity and recovery. PTEN and mTOR are 
      significant molecules within a signaling pathway that directly influences 
      dendritic sprouting, axonal plasticity, and regeneration. Expression levels of 
      PTEN, mTOR and downstream effectors within this pathway were investigated, and it 
      was found that following injury and IH exposure the expression of these molecules 
      was significantly altered. This study directly demonstrates the implementation 
      and feasibility of a non-invasive strategy to modulate the expression levels of 
      intrinsic signaling molecules known to influence plasticity and regeneration in 
      the CNS.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Gutierrez, Davina V
AU  - Gutierrez DV
AD  - Department of Neurosciences, MetroHealth Medical Center, Case Western Reserve 
      University School of Medicine, Cleveland, OH, USA.
FAU - Clark, Megan
AU  - Clark M
FAU - Nwanna, Obinna
AU  - Nwanna O
FAU - Alilain, Warren J
AU  - Alilain WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130528
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (Pten protein, rat)
SB  - IM
MH  - Animals
MH  - Cervical Vertebrae
MH  - Female
MH  - Hypoxia/*metabolism
MH  - Motor Neurons/metabolism
MH  - PTEN Phosphohydrolase/*metabolism
MH  - Phrenic Nerve/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function
MH  - Spinal Cord Injuries/*metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Breathing
OT  - C2 hemisection
OT  - IH
OT  - Intermittent hypoxia
OT  - PTEN
OT  - Phrenic motor neurons
OT  - Plasticity
OT  - SCI
OT  - Spinal cord injury
OT  - cervical level 2 hemisection
OT  - intermittent hypoxia
OT  - mTOR
OT  - spinal cord injury
EDAT- 2013/06/04 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/06/04 06:00
PHST- 2013/02/28 00:00 [received]
PHST- 2013/05/20 00:00 [revised]
PHST- 2013/05/21 00:00 [accepted]
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0014-4886(13)00159-3 [pii]
AID - 10.1016/j.expneurol.2013.05.013 [doi]
PST - ppublish
SO  - Exp Neurol. 2013 Oct;248:45-52. doi: 10.1016/j.expneurol.2013.05.013. Epub 2013 
      May 28.