PMID- 23727181
OWN - NLM
STAT- MEDLINE
DCOM- 20140131
LR  - 20130709
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 148
IP  - 3
DP  - 2013 Jul 30
TI  - Effects of taraxasterol on ovalbumin-induced allergic asthma in mice.
PG  - 787-93
LID - S0378-8741(13)00341-3 [pii]
LID - 10.1016/j.jep.2013.05.006 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Taraxasterol was isolated from the Chinese 
      medicinal herb Taraxacum officinale which has been frequently used as a remedy 
      for inflammatory diseases. In the present study, we determined the in vivo 
      protective effect of taraxasterol on allergic asthma induced by ovalbumin (OVA) 
      in mice. MATERIALS AND METHODS: Mice were sensitized and challenged with OVA, and 
      were orally treated daily with taraxasterol at 2.5, 5 and 10mg/kg from day 23 to 
      27 after sensitization. The number of inflammatory cells in bronchoalveolar 
      lavage fluid (BALF) was determined. Th2 cytokine interleukin-4 (IL-4), 
      interleukin-5 (IL-5), interleukin-13 (IL-13) production in BALF and OVA-specific 
      immunoglobulin E (IgE) production in sera were measured using ELISA. Histological 
      changes in lung tissues were examined using hematoxylin and eosin (H&E) and 
      periodic acid-Schiff staining (PAS). Airway hyperresponsiveness (AHR) to inhaled 
      methacholine was assessed. RESULTS: Taraxasterol dramatically decreased the total 
      inflammatory cell and main inflammatory cell counts, reduced the production of 
      Th2 cytokine IL-4, IL-5, IL-13 in BALF and OVA-specific IgE in sera, and 
      suppressed AHR in a dose-dependent manner. Histological studies demonstrated that 
      taraxasterol substantially suppressed OVA-induced inflammatory cells infiltration 
      into lung tissues and goblet cell hyperplasia in airways. CONCLUSIONS: This 
      finding suggests that taraxasterol protects against OVA-induced allergic asthma 
      in mice.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Liu, Jingtao
AU  - Liu J
AD  - Department of Animal Medicine, Agricultural College of Yanbian University, 
      Gongyuan Street, Yanji, Jilin 133002, PR China.
FAU - Xiong, Huanzhang
AU  - Xiong H
FAU - Cheng, Yao
AU  - Cheng Y
FAU - Cui, Chengdu
AU  - Cui C
FAU - Zhang, Xian
AU  - Zhang X
FAU - Xu, Lu
AU  - Xu L
FAU - Zhang, Xuemei
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130529
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Allergens)
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Sterols)
RN  - 0 (Triterpenes)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 64SK2ERN9P (taraxasterol)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Anti-Allergic Agents/pharmacology/*therapeutic use
MH  - Asthma/*drug therapy/immunology/pathology/physiopathology
MH  - Bronchial Hyperreactivity/*drug therapy/immunology/pathology/physiopathology
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Cytokines/immunology
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Lung/drug effects/immunology/pathology/physiopathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - Sterols/pharmacology/*therapeutic use
MH  - Triterpenes/pharmacology/*therapeutic use
OTO - NOTNLM
OT  - Airway inflammation
OT  - Allergic asthma
OT  - Immunoglobulin E (IgE)
OT  - Taraxasterol
OT  - Th2 cytokines
EDAT- 2013/06/04 06:00
MHDA- 2014/02/01 06:00
CRDT- 2013/06/04 06:00
PHST- 2012/10/13 00:00 [received]
PHST- 2013/02/25 00:00 [revised]
PHST- 2013/05/01 00:00 [accepted]
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/02/01 06:00 [medline]
AID - S0378-8741(13)00341-3 [pii]
AID - 10.1016/j.jep.2013.05.006 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2013 Jul 30;148(3):787-93. doi: 10.1016/j.jep.2013.05.006. Epub 
      2013 May 29.