PMID- 23727631
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20240109
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 21
IP  - 8
DP  - 2013 Aug
TI  - Randomized double-blind crossover study of the efficacy of a tart cherry juice 
      blend in treatment of osteoarthritis (OA) of the knee.
PG  - 1035-41
LID - S1063-4584(13)00802-9 [pii]
LID - 10.1016/j.joca.2013.05.009 [doi]
AB  - OBJECTIVE: To assess the efficacy of tart cherry juice in treating pain and other 
      features of knee osteoarthritis (OA). METHODS: 58 non-diabetic patients with 
      Kellgren grade 2-3 OA were randomized to begin treatment with cherry juice or 
      placebo. Two 8 oz bottles of tart cherry juice or placebo were consumed daily for 
      6 weeks with a 1 week washout period before switching treatments (crossover 
      design). Western Ontario McMaster Osteoarthritis Index (WOMAC) scores and walking 
      times were recorded prior to and after each treatment period. Additionally, 
      plasma urate, creatinine and high sensitivity C-reactive protein (hsCRP) were 
      recorded at baseline, after the first treatment period and after the second 
      treatment period. Acetaminophen was allowed as a rescue drug and self reported 
      after each treatment period. Treatment effect was examined with repeated measures 
      analysis of variance (ANOVA) using an intention-to-treat (ITT) analysis. RESULTS: 
      There were five withdrawals during the cherry juice treatment (four adverse 
      events (AEs)) and seven withdrawals during the placebo treatment (three AEs). 
      WOMAC scores decreased significantly (P < 0.01) after the cherry juice treatment 
      but not after the placebo treatment (P = 0.46); differences between treatments 
      were not significant (P = 0.16). hsCRP declined during the cherry juice treatment 
      vs placebo (P < 0.01). The decline in hsCRP was associated with WOMAC improvement 
      (P < 0.01). Walking time, acetaminophen use, plasma urate and creatinine were 
      unaffected by treatments. CONCLUSIONS: Tart cherry juice provided symptom relief 
      for patients with mild to moderate knee OA, but this effect was not significantly 
      greater than placebo. Tart cherry juice lowered hsCRP levels and this effect was 
      associated with improved WOMAC scores.
CI  - Copyright (c) 2013 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Schumacher, H R
AU  - Schumacher HR
AD  - University of Pennsylvania School of Medicine, and Philadelphia VA Medical 
      Center, Philadelphia, PA, USA. schumacr@mail.med.upenn.edu
FAU - Pullman-Mooar, S
AU  - Pullman-Mooar S
FAU - Gupta, S R
AU  - Gupta SR
FAU - Dinnella, J E
AU  - Dinnella JE
FAU - Kim, R
AU  - Kim R
FAU - McHugh, M P
AU  - McHugh MP
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130531
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (Biomarkers)
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Beverages/adverse effects
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Creatinine/blood
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/blood/*diet therapy
MH  - Pain Measurement/methods
MH  - Patient Compliance
MH  - *Prunus
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Uric Acid/blood
OTO - NOTNLM
OT  - C-reactive protein
OT  - Inflammation
OT  - Placebo
OT  - WOMAC
EDAT- 2013/06/04 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/06/04 06:00
PHST- 2013/01/09 00:00 [received]
PHST- 2013/04/10 00:00 [revised]
PHST- 2013/05/13 00:00 [accepted]
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - S1063-4584(13)00802-9 [pii]
AID - 10.1016/j.joca.2013.05.009 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2013 Aug;21(8):1035-41. doi: 
      10.1016/j.joca.2013.05.009. Epub 2013 May 31.