PMID- 23727642
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20211203
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 59
IP  - 2
DP  - 2013
TI  - Medium-chain triacylglycerol suppresses the decrease of plasma albumin level 
      through the insulin-Akt-mTOR pathway in the livers of malnourished rats.
PG  - 123-8
AB  - Recent studies have shown that medium-chain triacylglycerol (MCT) improved serum 
      albumin concentration in elderly people with protein-energy malnutrition (PEM) 
      and in malnourished rats. However, the mechanism for this effect has not been 
      clarified. Dietary MCT promotes insulin secretion from the pancreas, and insulin 
      activates mammalian target of rapamycin (mTOR) complex 1 (mTORC1) via the 
      activation of phosphoinositide 3-kinase (PI3K) and its downstream effecter, Akt. 
      mTORC1 promotes mRNA translation through S6K and 4E-BP1. Therefore, we 
      hypothesized that dietary MCT elevates albumin synthesis through promotion of 
      insulin-Akt-mTOR transduction in the liver. To test this hypothesis, we measured 
      phosphorylated Akt, mTOR and albumin in the livers of malnourished rats. In the 
      present study we examined rats fed low-protein diets containing either MCT or 
      long-chain triacylglycerol (LCT) with energy restriction. The plasma and liver 
      albumin levels were significantly higher in the MCT-fed group than in the LCT-fed 
      group. In addition, plasma insulin concentration, liver phosphorylated Akt/Akt 
      and phosphorylated mTOR/mTOR levels were significantly higher in the MCT-fed 
      group than in the LCT-fed group. These results suggest that one of the mechanisms 
      for the albumin improvement effect of dietary MCT is the promotion of albumin 
      synthesis through the insulin-Akt-mTOR signaling pathway of the liver.
FAU - Sekine, Seiji
AU  - Sekine S
AD  - Central Research Laboratory, The Nisshin OilliO Group, Ltd., 1 Shinmei-cho, 
      Yokosuka, Kanagawa, Japan. se-sekine@nisshin-oillio.com
FAU - Terada, Shin
AU  - Terada S
FAU - Aoyama, Toshiaki
AU  - Aoyama T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Carrier Proteins)
RN  - 0 (Eif4ebp1 protein, rat)
RN  - 0 (Insulin)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Phosphoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serum Albumin)
RN  - 0 (Triglycerides)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.1 (Rps6kb1 protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Carrier Proteins/genetics/metabolism
MH  - Diet, Protein-Restricted
MH  - Energy Intake
MH  - Insulin/*blood
MH  - Intracellular Signaling Peptides and Proteins
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Multiprotein Complexes/*metabolism
MH  - Muscle, Skeletal/drug effects
MH  - Organ Size/drug effects
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphoproteins/genetics/metabolism
MH  - Phosphorylation
MH  - Protein-Energy Malnutrition/drug therapy
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Ribosomal Protein S6 Kinases/genetics/metabolism
MH  - Serum Albumin/*biosynthesis
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Triglycerides/blood/*pharmacology
EDAT- 2013/06/04 06:00
MHDA- 2014/01/31 06:00
CRDT- 2013/06/04 06:00
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
AID - DN/JST.JSTAGE/jnsv/59.123 [pii]
AID - 10.3177/jnsv.59.123 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2013;59(2):123-8. doi: 10.3177/jnsv.59.123.