PMID- 23727892
OWN - NLM
STAT- MEDLINE
DCOM- 20140206
LR  - 20130724
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 4
IP  - 8
DP  - 2013 Aug
TI  - Anti-inflammatory effects of phenolic compounds isolated from the flowers of 
      Nymphaea mexicana Zucc.
PG  - 1216-22
LID - 10.1039/c3fo60041f [doi]
AB  - Nymphaea mexicana Zucc. is an aquatic plant species which belongs to the family 
      Nymphaea and is commonly known as the yellow water lily. The aim of this work was 
      to study the in vitro antiinflammatory effects of phenolic compounds isolated 
      from the flowers of Nymphaea mexicana Zucc. Seven phenolic compounds including 
      vanillic acid, 4-methoxy-3,5-dihydroxybenzoic acid, 
      (2R,3R)-3,7-dihydroxyflavanone, naringenin (4), kaempferol 
      3-O-(3-O-acetyl-a-L-rhamnopyranoside), kaempferol 
      3-O-(2-O-acetyl-a-L-rhamnopyranoside), and quercetin 3-(30 0-acetylrhamnoside) 
      (7) were isolated from the flowers of Nymphaea mexicana Zucc. These results 
      revealed that compound 4 has the most prominent inhibitory effect on the 
      LPS-stimulated nitric oxide (NO), monocyte chemotactic protein-1 (MCP-1), and 
      tumor necrosis factor-alpha (TNF-a) production in RAW 264.7 macrophages. In 
      addition, compound 4 also inhibited LPS-mediated induction of protein expressions 
      of inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), and 
      phospho-ERK in RAW 264.7 macrophages. Thus, compound 4 from the flowers of 
      Nymphaea mexicana Zucc. may provide a potential therapeutic approach for 
      inflammation-associated disorders.
FAU - Hsu, Chin-Lin
AU  - Hsu CL
AD  - School of Nutrition, Chung Shan Medical University and Department of Nutrition, 
      Chung Shan Medical University Hospital, No. 110, Section 1, Jianguo North Road, 
      Taichung 40201, Taiwan.
FAU - Fang, Song-Chwan
AU  - Fang SC
FAU - Yen, Gow-Chin
AU  - Yen GC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Phenols)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/isolation & purification/*pharmacology
MH  - Chemokine CCL2/genetics/immunology
MH  - Cyclooxygenase 2/genetics/immunology
MH  - Flowers/*chemistry
MH  - Macrophages/drug effects/immunology
MH  - Mice
MH  - Nitric Oxide/immunology
MH  - Nymphaea/*chemistry
MH  - Phenols/chemistry/isolation & purification/*pharmacology
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
EDAT- 2013/06/04 06:00
MHDA- 2014/02/07 06:00
CRDT- 2013/06/04 06:00
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/02/07 06:00 [medline]
AID - 10.1039/c3fo60041f [doi]
PST - ppublish
SO  - Food Funct. 2013 Aug;4(8):1216-22. doi: 10.1039/c3fo60041f.