PMID- 23728063
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20220309
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 461-462
DP  - 2013 Sep 1
TI  - Maternal diet, prenatal exposure to dioxins and other persistent organic 
      pollutants and anogenital distance in children.
PG  - 222-9
LID - S0048-9697(13)00548-2 [pii]
LID - 10.1016/j.scitotenv.2013.05.005 [doi]
AB  - We investigated the potential endocrine disruptive effect of prenatal exposure to 
      persistent organic pollutants (POPs) through maternal diet, by measuring 
      anogenital distance in newborns and young children. We included 231 mothers and 
      their newborns measured at birth from the Rhea study in Crete, Greece and the 
      Hmar study in Barcelona, Spain and 476 mothers and their children measured 
      between 1 and 2 years from the Rhea study. We used food frequency questionnaires 
      to assess maternal diet and estimated plasma dioxin-like activity by the 
      Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX(R)) and 
      other POPs in maternal samples. We defined a "high-fat diet" score, as a prenatal 
      exposure estimate, that incorporated intakes of red meat, processed meat, fatty 
      fish, seafood, eggs and high-fat dairy products during pregnancy. Increasing 
      maternal "high-fat diet" score was related to increasing dioxin-like activity and 
      serum concentrations of lipophilic persistent organic pollutants in maternal 
      blood. An inverse dose-response association was found between "high-fat diet" 
      score and anoscrotal distance in newborn males. The highest tertile of the 
      maternal score was associated with -4.2 mm (95% CI -6.6 to -1.8) reduction in 
      anoscrotal distance of newborn males, compared to the lowest tertile. A weak 
      positive association was found between the "high-fat diet" score and 
      anofourchetal distance in newborn females. In young children we found no 
      association between maternal "high-fat diet" score and anogenital distances. In 
      conclusion, maternal high-fat diet may be linked to high prenatal exposure to 
      persistent organic pollutants and endocrine disruptive effects, resulting to 
      phenotypic alterations of the reproductive system.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Papadopoulou, Eleni
AU  - Papadopoulou E
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
FAU - Vafeiadi, Marina
AU  - Vafeiadi M
FAU - Agramunt, Silvia
AU  - Agramunt S
FAU - Mathianaki, Kleopatra
AU  - Mathianaki K
FAU - Karakosta, Polyxeni
AU  - Karakosta P
FAU - Spanaki, Ariana
AU  - Spanaki A
FAU - Besselink, Harrie
AU  - Besselink H
FAU - Kiviranta, Hannu
AU  - Kiviranta H
FAU - Rantakokko, Panu
AU  - Rantakokko P
FAU - KaterinaSarri
AU  - KaterinaSarri
FAU - Koutis, Antonis
AU  - Koutis A
FAU - Chatzi, Leda
AU  - Chatzi L
FAU - Kogevinas, Manolis
AU  - Kogevinas M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130531
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Dioxins)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adult
MH  - Anal Canal/anatomy & histology
MH  - Anthropometry
MH  - Cohort Studies
MH  - Diet, High-Fat/*adverse effects
MH  - Dioxins/blood/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Genitalia/drug effects/*pathology
MH  - Gestational Age
MH  - Greece
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood/toxicity
MH  - Infant
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*pathology
MH  - Spain
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Anogenital distance
OT  - DR-CALUX
OT  - Maternal diet
OT  - Persistent organic pollutants
OT  - Pregnancy
OT  - Rhea study
EDAT- 2013/06/04 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/06/04 06:00
PHST- 2013/03/21 00:00 [received]
PHST- 2013/05/02 00:00 [revised]
PHST- 2013/05/02 00:00 [accepted]
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - S0048-9697(13)00548-2 [pii]
AID - 10.1016/j.scitotenv.2013.05.005 [doi]
PST - ppublish
SO  - Sci Total Environ. 2013 Sep 1;461-462:222-9. doi: 
      10.1016/j.scitotenv.2013.05.005. Epub 2013 May 31.