PMID- 23729563
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20140918
IS  - 2191-0286 (Electronic)
IS  - 0792-6855 (Linking)
VI  - 25
IP  - 1
DP  - 2014 Feb
TI  - Testosterone promotes glucose intolerance, lipid disorder and oxidative stress in 
      type 1 diabetic rats.
PG  - 13-20
LID - 10.1515/jbcpp-2012-0072 [doi]
AB  - BACKGROUND: A bidirectional relationship has been established between 
      testosterone deficiency (TD) and type 2 diabetes mellitus (T2DM). Low 
      testosterone level has been reported to be a predisposing factor to T2DM, whereas 
      recent clinical studies have shown a high prevalence of low testosterone in 
      diabetic individuals. However, it is not known if any relationship exists between 
      type 1 diabetes mellitus (T1DM) and testosterone level. This study was designed 
      to investigate the effects of TD on T1DM. Twenty-four Sprague-Dawley rats were 
      randomly divided into four groups designated as control, diabetic, orchiectomized 
      and orchiectomized-diabetic. METHODS: Diabetes was induced with an intravenous 
      injection of alloxan, and orchiectomy was done under sterile conditions. Fasting 
      blood glucose (FBG), insulin level, lipid and oxidative parameters were 
      determined in all experimental rats. RESULTS: The area under the curve during 
      oral glucose tolerance test showed that the orchiectomized-diabetic group 
      expressed an enhanced ability to metabolize glucose than the diabetic group. The 
      malondialdehyde level in the diabetic group was significantly higher compared 
      with that in the control and orchiectomized groups. Moreover, there was a 
      significant decrease in glutathione (GSH) activity and an increase in superoxide 
      dismutase activity in the diabetic group compared with control. Meanwhile, the 
      activities of GSH and catalase were significantly reduced in the orchiectomized 
      as well as the orchiectomized-diabetic group when compared with both control and 
      diabetic groups. CONCLUSIONS: These data indicate that TD attenuates glucose 
      intolerance under diabetic conditions and is equally associated with a 
      considerable reduction in oxidative stress, which implies that testosterone may 
      be a pro-oxidant.
FAU - Morakinyo, Ayodele Olufemi
AU  - Morakinyo AO
FAU - Adekunbi, Daniel Abiodun
AU  - Adekunbi DA
FAU - Dada, Kayode Akanni
AU  - Dada KA
FAU - Adegoke, Olufeyi Adefunke
AU  - Adegoke OA
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Basic Clin Physiol Pharmacol
JT  - Journal of basic and clinical physiology and pharmacology
JID - 9101750
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 3XMK78S47O (Testosterone)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Catalase/blood
MH  - Diabetes Mellitus, Experimental/complications/*metabolism
MH  - Glucose Intolerance/blood/complications/*metabolism
MH  - Glucose Tolerance Test
MH  - Glutathione/blood
MH  - Insulin/blood
MH  - Lipids/*blood
MH  - Male
MH  - Malondialdehyde/blood
MH  - Orchiectomy
MH  - *Oxidative Stress
MH  - Rats
MH  - Superoxide Dismutase/blood
MH  - Testosterone/blood/deficiency/*metabolism
EDAT- 2013/06/05 06:00
MHDA- 2015/06/16 06:00
CRDT- 2013/06/05 06:00
PHST- 2013/11/24 00:00 [received]
PHST- 2013/04/02 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - /j/jbcpp.ahead-of-print/jbcpp-2012-0072/jbcpp-2012-0072.xml [pii]
AID - 10.1515/jbcpp-2012-0072 [doi]
PST - ppublish
SO  - J Basic Clin Physiol Pharmacol. 2014 Feb;25(1):13-20. doi: 
      10.1515/jbcpp-2012-0072.