PMID- 23730959 OWN - NLM STAT- MEDLINE DCOM- 20150928 LR - 20220408 IS - 1601-0825 (Electronic) IS - 1354-523X (Linking) VI - 20 IP - 4 DP - 2014 May TI - Elevated serum IgE in recurrent aphthous stomatitis and associations with disease characteristics. PG - 386-94 LID - 10.1111/odi.12131 [doi] AB - OBJECTIVES: To characterize demographic, clinical and serological parameters in recurrent aphthous stomatitis (RAS) patients and analyse their association with serum immunoglobulin E (IgE) levels. SUBJECTS AND METHODS: Forty-nine patients with RAS responded to a questionnaire that included demographic background, stress status, smoking habits, history and course of RAS episodes. They were also subjected to relevant laboratory tests, including determination of serum IgE levels. RESULTS: A familial history of RAS was reported by 47.9% of the patients, stress in the previous year by 51.1% and smoking by 18.4%. Non-Caucasian origin, familial history of RAS, stress and smoking were associated with increased severity of RAS episodes. Haematological deficiencies were observed in 18.7% of RAS patients. Average IgE levels were increased and were significantly associated ‎with younger ‎age, ‎