PMID- 23732561
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20131008
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Linking)
VI  - 39
DP  - 2013 Sep-Oct
TI  - Thermoregulatory deficits in adult Long Evans rat exposed perinatally to the 
      antithyroidal drug, propylthiouracil.
PG  - 1-8
LID - S0892-0362(13)00153-0 [pii]
LID - 10.1016/j.ntt.2013.05.005 [doi]
AB  - Developmental exposure to endocrine disrupting drugs and environmental toxicants 
      has been shown to alter a variety of physiological processes in mature offspring. 
      Body (core) temperature (T(c)) is a tightly regulated homeostatic system but is 
      susceptible to disruptors of the hypothalamic pituitary thyroid (HPT) axis. We 
      hypothesized that thermoregulation would be disrupted in adult offspring exposed 
      perinatally to an HPT disruptor. Propylythiouracil (PTU) was used as a 
      prototypical compound because of its well known antithyroidal properties. PTU was 
      added to the drinking water of pregnant rats in concentrations of 0, 1, 2, 3, and 
      10 ppm from gestational day (GD) 6 through postnatal day (PND) 21. Adult male 
      offspring were implanted with radiotransmitters to monitor Tc and motor activity 
      (MA) and were observed undisturbed at an ambient temperature of 22  degrees C for 12 
      consecutive days. Data were averaged into a single 24 hour period to minimize 
      impact of ultradian changes in T(c) and MA. All treatment groups showed a 
      distinct circadian temperature rhythm. Rats exposed to 10 ppm PTU exhibited a 
      marked deviation in their regulated T(c) with a reduction of approximately 0.4  degrees C 
      below that of controls throughout the daytime period and a smaller reduction at 
      night. Rats exposed to 1 or 2 ppm also had smaller but significant reductions in 
      T(c). MA was unaffected by PTU. Overall, developmental exposure to moderate doses 
      of an antithyroidal drug led to an apparent permanent reduction in T(c) of adult 
      offspring that was independent of changes in MA.
CI  - Published by Elsevier Inc.
FAU - Johnstone, Andrew F M
AU  - Johnstone AF
AD  - Toxicology Assessment Division, National Health and Environmental Effects 
      Research Laboratory, Office of Research and Development, U.S. Environmental 
      Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: 
      johnstone.andrew@epa.gov.
FAU - Gilbert, Mary E
AU  - Gilbert ME
FAU - Aydin, Cenk
AU  - Aydin C
FAU - Grace, Curtis E
AU  - Grace CE
FAU - Hasegawa, Masashi
AU  - Hasegawa M
FAU - Gordon, Christopher J
AU  - Gordon CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130531
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Antithyroid Agents)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 721M9407IY (Propylthiouracil)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Antithyroid Agents/*toxicity
MH  - Body Temperature Regulation/*drug effects
MH  - Body Weight/drug effects
MH  - Circadian Rhythm/drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Male
MH  - Monitoring, Physiologic
MH  - Motor Activity/drug effects/physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/physiopathology
MH  - Propylthiouracil/*toxicity
MH  - Rats
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
OTO - NOTNLM
OT  - Core body temperature
OT  - Developmental exposure
OT  - GD
OT  - Gestational day
OT  - HPT
OT  - Homeostasis
OT  - Hypothalamic pituitary thyroid axis
OT  - Hypothyroidism
OT  - MA
OT  - Motor activity
OT  - PND
OT  - PTU
OT  - Parts-per-million
OT  - Postnatal day
OT  - Propylthiouracil
OT  - Propylthiouracil (PTU)
OT  - Tc
OT  - Telemetry
OT  - Thermoregulation
OT  - ppm
EDAT- 2013/06/05 06:00
MHDA- 2014/11/19 06:00
CRDT- 2013/06/05 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2013/05/13 00:00 [revised]
PHST- 2013/05/15 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - S0892-0362(13)00153-0 [pii]
AID - 10.1016/j.ntt.2013.05.005 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2013 Sep-Oct;39:1-8. doi: 10.1016/j.ntt.2013.05.005. Epub 
      2013 May 31.