PMID- 2373296
OWN - NLM
STAT- MEDLINE
DCOM- 19900830
LR  - 20190907
IS  - 0272-0590 (Print)
IS  - 0272-0590 (Linking)
VI  - 15
IP  - 1
DP  - 1990 Jul
TI  - Age-related changes in dermal absorption of 2,3,7, 8-tetrachlorodibenzo-p-dioxin 
      and 2,3,4,7,8-pentachlorodibenzofuran.
PG  - 163-73
AB  - Changes in the structure and function of aged skin may alter percutaneous 
      absorption of environmental compounds such as the halogenated aromatic 
      hydrocarbons. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and 
      2,3,4,7,8-penta-chlorodibenzofuran (4PeCDF) were previously found to be poorly 
      absorbed in 3 months male Fischer 344 rats within 3 days after dermal 
      administration. In order to examine age-related changes in dermal absorption and 
      changes in potential for systemic exposure, the absorption, distribution, and 
      elimination of TCDD and 4PeCDF were examined in male Fischer 344 rats of various 
      ages (TCDD: 10, 36, and 96 week; 4PeCDF: 10, 36, 64, 96, and 120 week). Each 
      compound was applied at a dose of 0.1 mumol/kg and/or 0.04 mumol in 60 
      microliters acetone to a preclipped region of the back and covered with a 
      stainless-steel perforated cap. Rats were housed in individual metabolism cages 
      for 3 days. Dermal absorption of both compounds was decreased in older age groups 
      compared to 10 week rats. The major tissue depots for both compounds were liver, 
      adipose, skin, and muscle and in comparable age groups, the liver:fat ratio was 
      greater in 4PeCDF-treated animals. Age-related changes in the distribution of the 
      administered dose and the absorbed dose varied with the compound as well as the 
      depot. Elimination of TCDD and 4PeCDF was limited at all ages. Results indicate 
      that percutaneous absorption of these compounds is decreased in older animals, 
      suggesting that systemic bioavailability may be decreased in older organisms 
      following dermal exposure to TCDD or 4PeCDF.
FAU - Banks, Y B
AU  - Banks YB
AD  - Experimental Toxicology Branch, National Institute of Environmental Health 
      Sciences, Reseach Triangle Park, North Carolina 27709.
FAU - Brewster, D W
AU  - Brewster DW
FAU - Birnbaum, L S
AU  - Birnbaum LS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Fundam Appl Toxicol
JT  - Fundamental and applied toxicology : official journal of the Society of 
      Toxicology
JID - 8200838
RN  - 0 (Benzofurans)
RN  - 0 (Dioxins)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - U4C2RV3124 (2,3,4,7,8-pentachlorodibenzofuran)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Benzofurans/*pharmacokinetics/urine
MH  - Body Composition/drug effects
MH  - Dioxins/*pharmacokinetics
MH  - Feces/analysis
MH  - Male
MH  - Polychlorinated Dibenzodioxins/*pharmacokinetics/urine
MH  - Rats
MH  - Rats, Inbred F344
MH  - Skin Absorption/*physiology
MH  - Tissue Distribution
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
AID - 10.1016/0272-0590(90)90173-h [doi]
PST - ppublish
SO  - Fundam Appl Toxicol. 1990 Jul;15(1):163-73. doi: 10.1016/0272-0590(90)90173-h.