PMID- 23733090 OWN - NLM STAT- MEDLINE DCOM- 20140106 LR - 20130604 IS - 1537-1603 (Electronic) IS - 0736-0258 (Linking) VI - 30 IP - 3 DP - 2013 Jun TI - EEG alpha power as an intermediate measure between brain-derived neurotrophic factor Val66Met and depression severity in patients with major depressive disorder. PG - 261-7 LID - 10.1097/WNP.0b013e3182933d6e [doi] AB - Major depressive disorder has a large impact on patients and society and is projected to be the second greatest global burden of disease by 2020. The brain-derived neurotrophic factor (BDNF) gene is considered to be one of the important factors in the etiology of major depressive disorder. In a recent study, alpha power was found to mediate between BDNF Met and subclinical depressed mood. The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity. For this purpose, repeated-measures analysis of variance, partial correlation, and multiple linear models were used. Results indicated a negative association between parietal-occipital alpha power in the eyes open resting state and depression severity. In addition, Met/Met patients showed lower global absolute alpha power in the eyes closed condition compared with Val-carriers. These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity. Additional research is needed for the clarification of this tentative pathway and its implication in personalized treatment of major depressive disorder. FAU - Zoon, Harriet F A AU - Zoon HF AD - Research Institute Brainclinics, Nijmegen, The Netherlands. FAU - Veth, C P M AU - Veth CP FAU - Arns, Martijn AU - Arns M FAU - Drinkenburg, W H I M AU - Drinkenburg WH FAU - Talloen, Willem AU - Talloen W FAU - Peeters, Pieter J AU - Peeters PJ FAU - Kenemans, J L AU - Kenemans JL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Neurophysiol JT - Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society JID - 8506708 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - *Alpha Rhythm MH - Brain-Derived Neurotrophic Factor/*genetics MH - Depression/*diagnosis/epidemiology/*genetics MH - Depressive Disorder, Major/*diagnosis/epidemiology/*genetics MH - Female MH - Genetic Predisposition to Disease/epidemiology/genetics MH - Humans MH - Male MH - Netherlands/epidemiology MH - Prevalence MH - Reproducibility of Results MH - Risk Factors MH - Sensitivity and Specificity MH - *Severity of Illness Index EDAT- 2013/06/05 06:00 MHDA- 2014/01/07 06:00 CRDT- 2013/06/05 06:00 PHST- 2013/06/05 06:00 [entrez] PHST- 2013/06/05 06:00 [pubmed] PHST- 2014/01/07 06:00 [medline] AID - 00004691-201306000-00006 [pii] AID - 10.1097/WNP.0b013e3182933d6e [doi] PST - ppublish SO - J Clin Neurophysiol. 2013 Jun;30(3):261-7. doi: 10.1097/WNP.0b013e3182933d6e.