PMID- 2373493 OWN - NLM STAT- MEDLINE DCOM- 19900830 LR - 20191029 IS - 0278-0232 (Print) IS - 0278-0232 (Linking) VI - 8 IP - 3 DP - 1990 May-Jun TI - Human T-cell lymphotropic virus type I (HTLV-I) antibodies in pre-diagnostic serum of patients with familial adult T-cell leukemia/lymphoma (ATL). PG - 169-76 AB - In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non-Hodgkin's lymphoma were identified after a follow-up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T-cell leukemia/lymphoma (ATL). Both of these brothers had human T-cell lymphotropic virus type I (HTLV-I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV-I antibody positive. This finding lends further support for a role of HTLV-I in the etiology of adult T-cell leukemia/lymphoma. FAU - Nomura, A M AU - Nomura AM AD - Kuakini Medical Center, Honolulu, HI 96817. FAU - Yanagihara, E T AU - Yanagihara ET FAU - Blattner, W A AU - Blattner WA FAU - Ho, G Y AU - Ho GY FAU - Inamasu, M S AU - Inamasu MS FAU - Severson, R K AU - Severson RK FAU - Nakamura, J M AU - Nakamura JM LA - eng GR - N01 CP 51023/CP/NCI NIH HHS/United States GR - R01 CA 33644/CA/NCI NIH HHS/United States PT - Case Reports PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - Hematol Oncol JT - Hematological oncology JID - 8307268 RN - 0 (HTLV-I Antibodies) SB - IM MH - Aged MH - HTLV-I Antibodies/*analysis MH - Hawaii MH - Humans MH - Japan/ethnology MH - Leukemia/microbiology MH - Leukemia-Lymphoma, Adult T-Cell/*diagnosis/genetics MH - Lymphoma/microbiology MH - Male MH - Middle Aged MH - Preleukemia/*microbiology EDAT- 1990/05/01 00:00 MHDA- 1990/05/01 00:01 CRDT- 1990/05/01 00:00 PHST- 1990/05/01 00:00 [pubmed] PHST- 1990/05/01 00:01 [medline] PHST- 1990/05/01 00:00 [entrez] AID - 10.1002/hon.2900080308 [doi] PST - ppublish SO - Hematol Oncol. 1990 May-Jun;8(3):169-76. doi: 10.1002/hon.2900080308.