PMID- 23734938
OWN - NLM
STAT- MEDLINE
DCOM- 20140408
LR  - 20231213
IS  - 1600-0609 (Electronic)
IS  - 0902-4441 (Linking)
VI  - 91
IP  - 3
DP  - 2013 Sep
TI  - Natural killer expansion, human leukocyte antigens-E expression and CD14(+) 
      CD56(+) monocytes in a myelodysplastic syndrome patient.
PG  - 265-269
LID - 10.1111/ejh.12152 [doi]
AB  - Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective 
      hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell 
      defects and of immune-mediated mechanisms was evidenced as relevant for 
      pathophysiology of MDS. Here, we described one case of MDS patient carrying 
      CD14(+) CD56(+) monocytes in bone marrow (BM), in the presence of a defective 
      human leukocyte antigen (HLA)-E expression on peripheral blood (PB) cells and of 
      natural killer (NK) cell expansion in PB and BM. The defective HLA-E expression 
      and the NK expansion are proposed to be relevant for the pathogenesis of 
      myelodysplasia in those patients showing CD14(+) CD56(+) monocytes in BM.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Terrazzano, Giuseppe
AU  - Terrazzano G
AD  - Department of Science, University of Basilicata, Potenza, Italy.
AD  - Department of Translational Medical Sciences, University of Naples "Federico II", 
      Naples, Italy.
FAU - Rubino, Valentina
AU  - Rubino V
AD  - Department of Translational Medical Sciences, University of Naples "Federico II", 
      Naples, Italy.
FAU - Palatucci, Anna Teresa
AU  - Palatucci AT
AD  - Department of Translational Medical Sciences, University of Naples "Federico II", 
      Naples, Italy.
FAU - Giovazzino, Angela
AU  - Giovazzino A
AD  - Department of Translational Medical Sciences, University of Naples "Federico II", 
      Naples, Italy.
FAU - Annunziatella, Mariangela
AU  - Annunziatella M
AD  - Department of Translational Medical Sciences, University of Naples "Federico II", 
      Naples, Italy.
FAU - Vitagliano, Orsola
AU  - Vitagliano O
AD  - Department of Clinical Medicine and Surgery, University of Naples "Federico II", 
      Naples, Italy.
FAU - Alfinito, Fiorella
AU  - Alfinito F
AD  - Department of Clinical Medicine and Surgery, University of Naples "Federico II", 
      Naples, Italy.
FAU - Ruggiero, Giuseppina
AU  - Ruggiero G
AD  - Department of Translational Medical Sciences, University of Naples "Federico II", 
      Naples, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130628
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 0 (Antigens, CD)
RN  - 0 (CD56 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Lipopolysaccharide Receptors)
SB  - IM
MH  - Aged, 80 and over
MH  - Antigens, CD/metabolism
MH  - CD56 Antigen/metabolism
MH  - Histocompatibility Antigens Class I/immunology/*metabolism
MH  - Humans
MH  - Immunophenotyping
MH  - Killer Cells, Natural/cytology/*immunology
MH  - Lipopolysaccharide Receptors/metabolism
MH  - Male
MH  - Monocytes/*immunology/*metabolism
MH  - Myelodysplastic Syndromes/genetics/*immunology/*metabolism
MH  - HLA-E Antigens
OTO - NOTNLM
OT  - CD94/NKG2 receptors
OT  - human leukocyte antigens-E
OT  - immune-mediated etiopathogenesis
OT  - myelodysplastic syndromes
OT  - natural killer
EDAT- 2013/06/06 06:00
MHDA- 2014/04/09 06:00
CRDT- 2013/06/06 06:00
PHST- 2013/05/29 00:00 [accepted]
PHST- 2013/06/06 06:00 [entrez]
PHST- 2013/06/06 06:00 [pubmed]
PHST- 2014/04/09 06:00 [medline]
AID - 10.1111/ejh.12152 [doi]
PST - ppublish
SO  - Eur J Haematol. 2013 Sep;91(3):265-269. doi: 10.1111/ejh.12152. Epub 2013 Jun 28.