PMID- 23737409
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130606
LR  - 20211021
IS  - 1723-8617 (Print)
IS  - 2051-5545 (Electronic)
IS  - 1723-8617 (Linking)
VI  - 12
IP  - 2
DP  - 2013 Jun
TI  - Future perspectives on the treatment of cognitive deficits and negative symptoms 
      in schizophrenia.
PG  - 99-107
LID - 10.1002/wps.20026 [doi]
AB  - Drug discovery based on classic models for cognitive impairment and negative 
      symptoms of schizophrenia have met with only modest success. Because cognitive 
      impairment and negative symptoms may result from disruptions in neurodevelopment, 
      more complex developmental models that integrate environmental and genetic risk 
      factors are needed. In addition, it has become clear that biochemical pathways 
      involved in schizophrenia form complex, interconnected networks. Points at which 
      risk factors converge, such as brain-derived neurotrophic factor (BDNF) and 
      protein kinase B (AKT), and from which processes involved in neuroplasticity 
      diverge, are of particular interest for pharmacologic interventions. This paper 
      reviews elements of neurodevelopmental models for cognitive deficits and negative 
      symptoms of schizophrenia with the aim of identifying potential targets for 
      interventions.
CI  - Copyright (c) 2013 World Psychiatric Association.
FAU - Goff, Donald C
AU  - Goff DC
AD  - Nathan Kline Institute for Psychiatric Research, New York University School of 
      Medicine, 140 Old Orangeburg Road, Orangeburg, NY, 10962, USA.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - World Psychiatry
JT  - World psychiatry : official journal of the World Psychiatric Association (WPA)
JID - 101189643
PMC - PMC3683252
EDAT- 2013/06/06 06:00
MHDA- 2013/06/06 06:01
PMCR- 2013/06/01
CRDT- 2013/06/06 06:00
PHST- 2013/06/06 06:00 [entrez]
PHST- 2013/06/06 06:00 [pubmed]
PHST- 2013/06/06 06:01 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.1002/wps.20026 [doi]
PST - ppublish
SO  - World Psychiatry. 2013 Jun;12(2):99-107. doi: 10.1002/wps.20026.