PMID- 23737549 OWN - NLM STAT- MEDLINE DCOM- 20150204 LR - 20211021 IS - 1745-1701 (Electronic) IS - 0586-7614 (Print) IS - 0586-7614 (Linking) VI - 40 IP - 4 DP - 2014 Jul TI - White matter microstructure in individuals at clinical high risk of psychosis: a whole-brain diffusion tensor imaging study. PG - 895-903 LID - 10.1093/schbul/sbt079 [doi] AB - BACKGROUND: The study of individuals at clinical high risk (CHR) for psychosis provides an important opportunity for unraveling pathological mechanisms underlying schizophrenia and related disorders. A small number of diffusion tensor magnetic resonance imaging (DTI) studies in CHR samples have yielded anatomically inconsistent results. The present study is the first to apply tract-based spatial statistics (TBSS) to perform a whole-brain DTI analysis in CHR subjects. METHODS: A total of 28 individuals meeting CHR criteria and 34 healthy controls underwent DTI. TBSS was used for a group comparison of fractional anisotropy (FA), as well as axial, radial, and mean diffusivity (AD, RD, and MD). Conversion to psychosis was monitored during a mean follow-up period of 12.3 months. RESULTS: The rate of conversion to psychosis was relatively low (4%). TBSS revealed increased MD in several clusters in the right hemisphere, most notably in the superior longitudinal fasciculus (SLF), posterior corona radiata, and corpus callosum (splenium and body). Increased RD was restricted to a smaller area in the posterior parietal lobe. CONCLUSION: We present further evidence that white matter microstructure is abnormal in CHR individuals, even in a sample in which the vast majority do not transition to psychosis over the following year. In accord with previous studies on CHR individuals and patients with early-onset schizophrenia, our findings suggest an important pathological role for the parietal lobe and especially the SLF. The latter is known to undergo particularly dynamic microstructural changes during adolescence and early adulthood, a critical phase for the development of psychotic illness. CI - (c) The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com. FAU - von Hohenberg, Christian Clemm AU - von Hohenberg CC AD - clemm@bwh.harvard.edu. FAU - Pasternak, Ofer AU - Pasternak O AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA; FAU - Kubicki, Marek AU - Kubicki M AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA; Department of Radiology, Harvard Medical School, Boston, MA; FAU - Ballinger, Thomas AU - Ballinger T AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; FAU - Vu, Mai-Anh AU - Vu MA AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; FAU - Swisher, Tali AU - Swisher T AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; FAU - Green, Katie AU - Green K AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; FAU - Giwerc, Michelle AU - Giwerc M AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; FAU - Dahlben, Brian AU - Dahlben B AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; FAU - Goldstein, Jill M AU - Goldstein JM AD - Department of Psychiatry, Harvard Medical School, Boston, MA; Departments of Psychiatry and Medicine, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; FAU - Woo, Tsung-Ung W AU - Woo TU AD - Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA; FAU - Petryshen, Tracey L AU - Petryshen TL AD - Department of Psychiatry, Harvard Medical School, Boston, MA; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA; FAU - Mesholam-Gately, Raquelle I AU - Mesholam-Gately RI AD - Department of Psychiatry, Harvard Medical School, Boston, MA; Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; FAU - Woodberry, Kristen A AU - Woodberry KA AD - Department of Psychiatry, Harvard Medical School, Boston, MA; Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; FAU - Thermenos, Heidi W AU - Thermenos HW AD - Department of Psychiatry, Harvard Medical School, Boston, MA; FAU - Mulert, Christoph AU - Mulert C AD - Psychiatry Neuroimaging Branch, Imaging Center NeuroImage Nord and Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; FAU - McCarley, Robert W AU - McCarley RW AD - Department of Psychiatry, Harvard Medical School, Boston, MA; Clinical Neuroscience Division, Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, MA. FAU - Seidman, Larry J AU - Seidman LJ AD - Department of Psychiatry, Harvard Medical School, Boston, MA; FAU - Shenton, Martha E AU - Shenton ME AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA; Department of Radiology, Harvard Medical School, Boston, MA; Clinical Neuroscience Division, Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, MA. LA - eng GR - UL1RR025758/RR/NCRR NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - P51 RR000168/RR/NCRR NIH HHS/United States GR - R01M H074794/PHS HHS/United States GR - P41RR14075/RR/NCRR NIH HHS/United States GR - 1S10RR019307/RR/NCRR NIH HHS/United States GR - 1S10RR023043/RR/NCRR NIH HHS/United States GR - 1S10RR023401/RR/NCRR NIH HHS/United States GR - M01RR01032/RR/NCRR NIH HHS/United States GR - UL1 RR025758/RR/NCRR NIH HHS/United States GR - P50 MH 080272/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20130604 PL - United States TA - Schizophr Bull JT - Schizophrenia bulletin JID - 0236760 SB - IM MH - Adolescent MH - Adult MH - Brain/pathology MH - Case-Control Studies MH - Corpus Callosum/*pathology MH - Diffusion Tensor Imaging MH - Female MH - Follow-Up Studies MH - Humans MH - Image Processing, Computer-Assisted MH - Male MH - Parietal Lobe/*pathology MH - *Prodromal Symptoms MH - Psychotic Disorders/*pathology MH - Risk MH - Schizophrenia/*pathology MH - White Matter/*pathology MH - Young Adult PMC - PMC4059424 OTO - NOTNLM OT - TBSS OT - diffusivity OT - mean OT - parietal lobe OT - prodrome OT - radial OT - schizophrenia EDAT- 2013/06/06 06:00 MHDA- 2015/02/05 06:00 PMCR- 2015/07/01 CRDT- 2013/06/06 06:00 PHST- 2013/06/06 06:00 [entrez] PHST- 2013/06/06 06:00 [pubmed] PHST- 2015/02/05 06:00 [medline] PHST- 2015/07/01 00:00 [pmc-release] AID - sbt079 [pii] AID - 10.1093/schbul/sbt079 [doi] PST - ppublish SO - Schizophr Bull. 2014 Jul;40(4):895-903. doi: 10.1093/schbul/sbt079. Epub 2013 Jun 4.