PMID- 23737803
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130618
LR  - 20220309
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2013
DP  - 2013
TI  - Progenitor Cell Therapy to Treat Acute Myocardial Infarction: The Promise of 
      High-Dose Autologous CD34(+) Bone Marrow Mononuclear Cells.
PG  - 658480
LID - 10.1155/2013/658480 [doi]
LID - 658480
AB  - ST elevation myocardial infarction (STEMI) is associated with an increased risk 
      for congestive heart failure and long-term mortality despite the widespread use 
      of thrombolysis and catheter-based revascularization. The need for improved 
      post-STEMI therapies has led to a surge of novel therapeutics, especially 
      regenerative approaches using autologous mononuclear cells. Indeed, the past 
      decade has been marked by a number of human trials studying the safety and 
      efficacy of progenitor cell delivery in the post-STEMI setting. While a variety 
      of cell types and delivery techniques have been utilized, directed therapy to the 
      infarct-related artery has been the most widely used approach. From over 1300 
      subjects randomized in these studies, there is sufficient evidence to conclude 
      that cell therapy after STEMI is uniformly safe, while the efficacy of this 
      intervention for improving outcomes is less clear. Recent meta-analyses have 
      highlighted the importance of both timing of cell delivery, as well as the type, 
      quantity, and mobility of delivered cells as determinants of response. Here, we 
      show the case in which higher doses of CD34(+) cells, which are more potent in 
      terms of their migratory capacity, offer the best hope for preserving cardiac 
      function following STEMI.
FAU - Poole, Joseph C
AU  - Poole JC
AD  - Emory University School of Medicine, Division of Cardiology, 319 Woodruff 
      Memorial Research Building, 1639 Pierce Drive, Suite 319, Atlanta, GA 30322, USA.
FAU - Quyyumi, Arshed A
AU  - Quyyumi AA
LA  - eng
GR  - P20 HL113451/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20130428
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3655659
EDAT- 2013/06/06 06:00
MHDA- 2013/06/06 06:01
PMCR- 2013/04/28
CRDT- 2013/06/06 06:00
PHST- 2012/10/19 00:00 [received]
PHST- 2013/03/18 00:00 [revised]
PHST- 2013/03/21 00:00 [accepted]
PHST- 2013/06/06 06:00 [entrez]
PHST- 2013/06/06 06:00 [pubmed]
PHST- 2013/06/06 06:01 [medline]
PHST- 2013/04/28 00:00 [pmc-release]
AID - 10.1155/2013/658480 [doi]
PST - ppublish
SO  - Stem Cells Int. 2013;2013:658480. doi: 10.1155/2013/658480. Epub 2013 Apr 28.