PMID- 23738468
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20130606
IS  - 1934-578X (Print)
IS  - 1555-9475 (Linking)
VI  - 8
IP  - 4
DP  - 2013 Apr
TI  - Effect on emotional behavior and stress by inhalation of the essential oil from 
      Chamaecyparis obtusa.
PG  - 515-8
AB  - Various effects have been reported in the literature for the essential oil from 
      Chamaecyparis obtusa (EOCO), such as antibacterial and antifungal activity. In 
      this study, we examined the effect of EOCO on emotional behavior and 
      stress-induced biomarkers. Male ICR mice, aged 5 weeks at the start of each 
      experiment, were individually housed in cages for 1 week. After placing each 
      mouse in a glass container and exposing it to EOCO for 90 min, we then 
      investigated the influence on emotional behavior using the elevated-plus maze 
      (EPM) test, which is one of the evaluation methods for anxiolytic-like behavior. 
      Significant anxiolytic-like effects were observed for the 7.0 mg/L air EOCO (P < 
      0.05). After the EPM test, mice were dissected and changes in the stress-induced 
      biomarkers within the brain were investigated by examining the amounts of fast 
      nerve growth factor receptor (NGFR) and activity regulated 
      cytoskeletal-associated protein (Arc) gene expression, and brain-derived 
      neurotrophic factor (BDNF) and galactokinase 1 (GLK1) protein expression. 
      Significant increases were observed in the amount of NGFR after inhalation of 7.0 
      mg/L air EOCO (P < 0.05). These results indicate that EOCO has both 
      anxiolytic-like and stress mitigation effects.
FAU - Kasuya, Hikaru
AU  - Kasuya H
AD  - Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, 
      Japan.
FAU - Hata, Erika
AU  - Hata E
FAU - Satou, Tadaaki
AU  - Satou T
FAU - Yoshikawa, Masaki
AU  - Yoshikawa M
FAU - Hayashi, Shinichiro
AU  - Hayashi S
FAU - Masuo, Yoshinori
AU  - Masuo Y
FAU - Koike, Kazuo
AU  - Koike K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nat Prod Commun
JT  - Natural product communications
JID - 101477873
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Oils, Volatile)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Anti-Anxiety Agents/*pharmacology
MH  - Chamaecyparis/*chemistry
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Oils, Volatile/*pharmacology
MH  - Receptors, Nerve Growth Factor/analysis
MH  - Stress, Psychological/*metabolism
EDAT- 2013/06/07 06:00
MHDA- 2013/08/13 06:00
CRDT- 2013/06/07 06:00
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
PST - ppublish
SO  - Nat Prod Commun. 2013 Apr;8(4):515-8.