PMID- 23739121
OWN - NLM
STAT- MEDLINE
DCOM- 20140212
LR  - 20130725
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 58
IP  - 7
DP  - 2013 Jul
TI  - DNA methylation of the BDNF gene and its relevance to psychiatric disorders.
PG  - 434-8
LID - 10.1038/jhg.2013.65 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor, which is 
      important for neuronal survival, development and synaptic plasticity. 
      Accumulating evidence suggests that epigenetic modifications of BDNF are 
      associated with the pathophysiology of psychiatric disorders, such as 
      schizophrenia and mood disorders. Patients with psychiatric disorders generally 
      show decreased neural BDNF levels, which are often associated with increased DNA 
      methylation at the specific BDNF promoters. Importantly, observed DNA methylation 
      changes are consistent across tissues including brain and peripheral blood, which 
      suggests potential usefulness of these findings as a biomarker of psychiatric 
      disorders. Here we review DNA methylation characteristics of BDNF promoters of 
      cellular, animal and clinical samples and discuss future perspectives.
FAU - Ikegame, Tempei
AU  - Ikegame T
AD  - Department of Molecular Psychiatry, Graduate School of Medicine, The University 
      of Tokyo, Tokyo, Japan.
FAU - Bundo, Miki
AU  - Bundo M
FAU - Murata, Yui
AU  - Murata Y
FAU - Kasai, Kiyoto
AU  - Kasai K
FAU - Kato, Tadafumi
AU  - Kato T
FAU - Iwamoto, Kazuya
AU  - Iwamoto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130606
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Autopsy
MH  - Brain/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - *DNA Methylation
MH  - Disease Models, Animal
MH  - Humans
MH  - Neurons/cytology/metabolism
MH  - Promoter Regions, Genetic
MH  - Schizophrenia/*genetics/physiopathology
EDAT- 2013/06/07 06:00
MHDA- 2014/02/13 06:00
CRDT- 2013/06/07 06:00
PHST- 2013/04/29 00:00 [received]
PHST- 2013/05/07 00:00 [revised]
PHST- 2013/05/11 00:00 [accepted]
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2014/02/13 06:00 [medline]
AID - jhg201365 [pii]
AID - 10.1038/jhg.2013.65 [doi]
PST - ppublish
SO  - J Hum Genet. 2013 Jul;58(7):434-8. doi: 10.1038/jhg.2013.65. Epub 2013 Jun 6.