PMID- 23739870
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20211021
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 132
IP  - 10
DP  - 2013 Oct
TI  - Responses to booster hepatitis B vaccination are significantly correlated with 
      genotypes of human leukocyte antigen (HLA)-DPB1 in neonatally vaccinated 
      adolescents.
PG  - 1131-9
LID - 10.1007/s00439-013-1320-5 [doi]
AB  - Genome-wide association studies have identified single nucleotide polymorphisms 
      (SNPs) near the human leukocyte antigen (HLA)-DP loci that were significantly 
      correlated with outcomes of hepatitis B virus (HBV) infection. We performed a 
      case-control study nested in a well-characterized cohort of booster recipients to 
      assess whether genetic variants of HLA-DPB1 are also associated with response to 
      hepatitis B (HB) vaccination. The cases and controls were 171 and 510 booster 
      recipients whose post-booster titers of antibodies against HBV surface antigen 
      (anti-HBs) were undetectable and detectable, respectively. The HLA-DPB1 genotype 
      was determined using sequence-based techniques. The frequencies of HLA-DPB1 
      alleles were significantly different between cases and controls 
      (p = 1.7 x 10(-8)). The HLA-DPB1 05:01 and 09:01 alleles were significantly more 
      frequent in the cases, and 02:01:02, 02:02, 03:01:01, 04:01:01, and 14:01, were 
      significantly more frequent in the controls. The adjusted odds ratio (OR) of 
      undetectable post-booster anti-HBs titers was significantly correlated with the 
      number of risk alleles (p for trend = 3.8 x 10(-5)). For the number of protective 
      alleles, the trend was significantly inversed (p for trend = 1.3 x 10(-5)). As 
      compared with subjects with two risk alleles, adjusted OR were 0.34 (95 % 
      confidence interval [CI] 0.21-0.55) and 0.20 (95 % CI 0.08-0.48) for subjects 
      with 1 and 2 protective alleles, respectively. The HLA-DPB1 02:02, 04:01:01, 
      05:01 and 09:01 alleles were also significantly correlated with the likelihoods 
      of undetectable pre-booster anti-HBs titers. Our results indicated that HLA-DPB1 
      is significantly correlated with response to booster HB vaccination in adolescent 
      who had received postnatal active HB vaccination. HLA-DBP1 may also determine the 
      long-term persistence of response to HB vaccination.
FAU - Wu, Tzu-Wei
AU  - Wu TW
AD  - Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Jhong-Jheng Rd., 
      San-Jhih Dist., New Taipei City, 252, Taiwan.
FAU - Chu, Chen-Chung
AU  - Chu CC
FAU - Ho, Tzu-Ying
AU  - Ho TY
FAU - Chang Liao, Huei-Wen
AU  - Chang Liao HW
FAU - Lin, Sheng-Kai
AU  - Lin SK
FAU - Lin, Marie
AU  - Lin M
FAU - Lin, Hans Hsienhong
AU  - Lin HH
FAU - Wang, Li-Yu
AU  - Wang LY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130606
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Loci
MH  - *Genotype
MH  - HLA-DP beta-Chains/*genetics/metabolism
MH  - Hepatitis B/prevention & control
MH  - Hepatitis B Antibodies/immunology
MH  - Hepatitis B Vaccines/*administration & dosage/*immunology
MH  - Humans
MH  - *Immunization, Secondary
MH  - Male
MH  - Odds Ratio
MH  - Risk Factors
MH  - Vaccination
EDAT- 2013/06/07 06:00
MHDA- 2013/11/05 06:00
CRDT- 2013/06/07 06:00
PHST- 2013/03/10 00:00 [received]
PHST- 2013/05/26 00:00 [accepted]
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - 10.1007/s00439-013-1320-5 [doi]
PST - ppublish
SO  - Hum Genet. 2013 Oct;132(10):1131-9. doi: 10.1007/s00439-013-1320-5. Epub 2013 Jun 
      6.