PMID- 23739920
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20220409
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 34
IP  - 6
DP  - 2014 Jun
TI  - Effect of exercise on the plasma BDNF levels in elderly women with knee 
      osteoarthritis.
PG  - 841-6
LID - 10.1007/s00296-013-2786-0 [doi]
AB  - Knee osteoarthritis is a common disease in the elderly population worldwide. The 
      alleviation of the symptoms associated with this disease can be achieved with 
      physical exercise that induces a cascade of molecular and cellular processes. Of 
      the neurotrophins, brain-derived neurotrophic factor (BDNF) appears to be the 
      most affected by physical activity. Moreover, BDNF seems to have a negative 
      modulatory role in inflammation, and its production by skeletal muscle cells or 
      by cells of the immune system drives the immunoprotective role of physical 
      activity in situations of chronic inflammation. Therefore, the aim of this study 
      was to evaluate plasma BDNF concentrations in elderly individuals presenting with 
      knee osteoarthritis. To accomplish this, sixteen volunteers (mean age 67 +/- 4.41 
      years) presenting with clinically and radiographically diagnosed knee 
      osteoarthritis were evaluated during acute exercise (1 session of 20 min on a 
      treadmill) and after chronic exercise (12 weeks of aerobic training, consisting 
      of a 50-min walk 3 times per week). Additionally, both a functional assessment 
      (during a 6-min walk) and a pain perception assessment were performed at the 
      start and at the end of physical exercises (training). The plasma BDNF 
      concentrations were measured by ELISA. For the population studied, acute exercise 
      increased the levels of BDNF only before the 12-week training period (p < 0.001). 
      Moreover, the training augmented the plasma concentrations of BDNF (p < 0.0001) 
      and improved clinical parameters (functional p < 0.001; pain perception p < 
      0.01).
FAU - Gomes, Wellington F
AU  - Gomes WF
AD  - Integrated Center for Graduate Studies and Research Health (CIPq-Health), Federal 
      University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas 
      Gerais, Brazil, wellingtonufvjm@gmail.com.
FAU - Lacerda, Ana Cristina R
AU  - Lacerda AC
FAU - Mendonca, Vanessa A
AU  - Mendonca VA
FAU - Arrieiro, Arthur N
AU  - Arrieiro AN
FAU - Fonseca, Sueli F
AU  - Fonseca SF
FAU - Amorim, Mateus R
AU  - Amorim MR
FAU - Teixeira, Antonio L
AU  - Teixeira AL
FAU - Teixeira, Mauro M
AU  - Teixeira MM
FAU - Miranda, Aline S
AU  - Miranda AS
FAU - Coimbra, Candido C
AU  - Coimbra CC
FAU - Brito-Melo, Gustavo E A
AU  - Brito-Melo GE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130606
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cohort Studies
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - *Exercise Therapy
MH  - Female
MH  - Humans
MH  - Osteoarthritis, Knee/blood/*therapy
MH  - Pain Perception/physiology
MH  - Treatment Outcome
EDAT- 2013/06/07 06:00
MHDA- 2015/01/06 06:00
CRDT- 2013/06/07 06:00
PHST- 2013/05/16 00:00 [received]
PHST- 2013/05/20 00:00 [accepted]
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.1007/s00296-013-2786-0 [doi]
PST - ppublish
SO  - Rheumatol Int. 2014 Jun;34(6):841-6. doi: 10.1007/s00296-013-2786-0. Epub 2013 
      Jun 6.