PMID- 23740228
OWN - NLM
STAT- MEDLINE
DCOM- 20140916
LR  - 20220330
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 73
IP  - 8
DP  - 2014 Aug
TI  - Disparity between ultrasound and clinical findings in psoriatic arthritis.
PG  - 1529-36
LID - 10.1136/annrheumdis-2012-203073 [doi]
AB  - OBJECTIVE: To investigate the association between psoriatic arthritis 
      (PsA)-specific clinical composite scores and ultrasound-verified pathology as 
      well as comparison of clinical and ultrasound definitions of remission. METHODS: 
      We performed a prospective study on 70 consecutive PsA patients. Clinical 
      assessments included components of Disease Activity Index for Psoriatic Arthritis 
      (DAPSA) and the Composite Psoriatic Disease Activity Index (CPDAI). Minimal 
      disease activity (MDA) and the following remission criteria were applied: CPDAI 
      joint, entheses and dactylitis domains (CPDAI-JED)=0, DAPSA</=3.3, Boolean's 
      remission definition and physician-judged remission (rem-phys). B-mode and power 
      Doppler (PD-) ultrasound findings were semiquantitatively scored at 68 joints 
      (evaluating synovia, peritendinous tissue, tendons and bony changes) and 14 
      entheses. Ultrasound remission and minimal ultrasound disease activity (MUDA) 
      were defined as PD-score=0 and PD-score </=1, respectively, at joints, 
      peritendinous tissue, tendons and entheses. RESULTS: DAPSA but not CPDAI 
      correlated with B-mode and PD-synovitis. Ultrasound signs of enthesitis, 
      dactylitis, tenosynovitis and perisynovitis were not linked with clinical 
      composites. Clinical remission or MDA was observed in 15.7% to 47.1% of PsA 
      patients. Ultrasound remission and MUDA were present in 4.3% and 20.0% of 
      patients, respectively. Joint and tendon-related PD-scores were higher in 
      patients with active versus inactive disease according to CPDAI-JED, DAPSA, 
      Boolean's and rem-phys, whereas no difference was observed regarding enthesitis 
      and perisynovitis. DAPSA</=3.3 (OR 3.9, p=0.049) and Boolean's definition (OR 4.6, 
      p=0.03) were more useful to predict MUDA than other remission criteria. 
      CONCLUSIONS: PsA-specific composite scores partially reflect ultrasound findings. 
      DAPSA and Boolean's remission definitions better identify MUDA patients than 
      other clinical criteria.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Husic, Rusmir
AU  - Husic R
AD  - Department of Rheumatology and Immunology, Medical University Graz, Graz, 
      Austria.
FAU - Gretler, Judith
AU  - Gretler J
AD  - Department of Rheumatology and Immunology, Medical University Graz, Graz, 
      Austria.
FAU - Felber, Anja
AU  - Felber A
AD  - Department of Rheumatology and Immunology, Medical University Graz, Graz, 
      Austria.
FAU - Graninger, Winfried B
AU  - Graninger WB
AD  - Department of Rheumatology and Immunology, Medical University Graz, Graz, 
      Austria.
FAU - Duftner, Christina
AU  - Duftner C
AD  - Department of Internal Medicine, General Hospital Kufstein, Kufstein, Austria.
FAU - Hermann, Josef
AU  - Hermann J
AD  - Department of Rheumatology and Immunology, Medical University Graz, Graz, 
      Austria.
FAU - Dejaco, Christian
AU  - Dejaco C
AD  - Department of Rheumatology and Immunology, Medical University Graz, Graz, 
      Austria.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130605
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Arthritis, Psoriatic/*diagnostic imaging/*pathology
MH  - Biomarkers
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Observer Variation
MH  - Prospective Studies
MH  - Remission Induction
MH  - Reproducibility of Results
MH  - *Severity of Illness Index
MH  - Tenosynovitis/*diagnostic imaging/*pathology
MH  - Ultrasonography/*methods/standards/statistics & numerical data
OTO - NOTNLM
OT  - DAS28
OT  - Disease Activity
OT  - Psoriatic Arthritis
OT  - Spondyloarthritis
OT  - Ultrasonography
EDAT- 2013/06/07 06:00
MHDA- 2014/09/17 06:00
CRDT- 2013/06/07 06:00
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2014/09/17 06:00 [medline]
AID - annrheumdis-2012-203073 [pii]
AID - 10.1136/annrheumdis-2012-203073 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2014 Aug;73(8):1529-36. doi: 10.1136/annrheumdis-2012-203073. Epub 
      2013 Jun 5.