PMID- 23740365
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20151119
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 5
IP  - 14
DP  - 2013 Jul 21
TI  - Lanthanide-doped NaScF4 nanoprobes: crystal structure, optical spectroscopy and 
      biodetection.
PG  - 6430-8
LID - 10.1039/c3nr01529g [doi]
AB  - Trivalent lanthanide ions (Ln(3+))-doped inorganic nanoparticles (NPs) as 
      potential luminescent bioprobes have been attracting tremendous interest because 
      of their unique upconversion (UC) and downconversion (DC) luminescence 
      properties. NaScF4, as an important host material, has been rarely reported and 
      its crystal structure remains unclear. Herein, based on the single crystal X-ray 
      diffraction, the space group of NaScF4 crystals was determined to be P31 
      containing multiple sites of Sc(3+) with crystallographic site symmetry of C1, 
      which was verified by high-resolution photoluminescence spectroscopy of Eu(3+) at 
      low temperature (10 K). Furthermore, monodisperse and size-controllable 
      NaScF4:Ln(3+) NPs were synthesized via a facile thermal decomposition method. The 
      biotinylated NaScF4:Er(3+)/Yb(3+) NPs were demonstrated for their applications as 
      a heterogeneous UC luminescence bioprobe to detect avidin with a detection limit 
      of 180 pM. After bioconjugation with amino-terminal fragment (ATF) of urokinase 
      plasminogen activator (uPA), NaScF4:Ln(3+) NPs also exhibited specific 
      recognition of cancer cells overexpressed with uPA receptor (uPAR, an important 
      marker of tumor biology and metastasis), showing great potentials in 
      tumor-targeted bioimaging.
FAU - Ai, Yu
AU  - Ai Y
AD  - Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian 
      Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 
      Fuzhou, Fujian 350002, China.
FAU - Tu, Datao
AU  - Tu D
FAU - Zheng, Wei
AU  - Zheng W
FAU - Liu, Yongsheng
AU  - Liu Y
FAU - Kong, Jintao
AU  - Kong J
FAU - Hu, Ping
AU  - Hu P
FAU - Chen, Zhuo
AU  - Chen Z
FAU - Huang, Mingdong
AU  - Huang M
FAU - Chen, Xueyuan
AU  - Chen X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130606
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Lanthanoid Series Elements)
RN  - 0 (Receptors, Urokinase Plasminogen Activator)
RN  - 0 (Sodium Compounds)
RN  - Q80VPU408O (Fluorides)
RN  - YUJ4U1EW7R (Scandium)
SB  - IM
MH  - Biomarkers, Tumor/metabolism
MH  - Biotinylation
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Crystallography, X-Ray
MH  - Fluorescent Dyes/chemistry/toxicity
MH  - Fluorides/*chemistry
MH  - Humans
MH  - Lanthanoid Series Elements/*chemistry
MH  - Microscopy, Confocal
MH  - Molecular Conformation
MH  - Nanoparticles/*chemistry/toxicity
MH  - Receptors, Urokinase Plasminogen Activator/metabolism
MH  - Scandium/*chemistry
MH  - Sodium Compounds/*chemistry
EDAT- 2013/06/07 06:00
MHDA- 2014/01/31 06:00
CRDT- 2013/06/07 06:00
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
AID - 10.1039/c3nr01529g [doi]
PST - ppublish
SO  - Nanoscale. 2013 Jul 21;5(14):6430-8. doi: 10.1039/c3nr01529g. Epub 2013 Jun 6.