PMID- 23740977
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20220311
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 87
IP  - 15
DP  - 2013 Aug
TI  - MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus 
      (PRRSV) infection by targeting PRRSV receptor CD163.
PG  - 8808-12
LID - 10.1128/JVI.00718-13 [doi]
AB  - We previously showed that microRNA 181 (miR-181) can inhibit PRRSV replication by 
      directly targeting its genomic RNA. Here, we report that miR-181 can downregulate 
      the PRRSV receptor CD163 in blood monocytes and porcine alveolar macrophages 
      (PAMs) through targeting the 3' untranslated region (UTR) of CD163 mRNA. 
      Downregulation of CD163 leads to the inhibition of PRRSV entry into PAMs and 
      subsequently suppresses PRRSV infection. Our findings indicate that delivery of 
      miR-181 can be used as antiviral therapy against PRRSV infection.
FAU - Gao, Li
AU  - Gao L
AD  - State Key Laboratory of Agrobiotechnology, China Agricultural University, 
      Beijing, China.
FAU - Guo, Xue-kun
AU  - Guo XK
FAU - Wang, Lianghai
AU  - Wang L
FAU - Zhang, Qiong
AU  - Zhang Q
FAU - Li, Ning
AU  - Li N
FAU - Chen, Xin-xin
AU  - Chen XX
FAU - Wang, Yongqiang
AU  - Wang Y
FAU - Feng, Wen-hai
AU  - Feng WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130605
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD163 antigen)
RN  - 0 (MicroRNAs)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Animals
MH  - Antigens, CD/genetics
MH  - Antigens, Differentiation, Myelomonocytic/genetics
MH  - Macrophages, Alveolar/virology
MH  - MicroRNAs/genetics/*metabolism
MH  - Monocytes/virology
MH  - Porcine respiratory and reproductive syndrome virus/*growth & 
      development/physiology
MH  - Receptors, Cell Surface/*antagonists & inhibitors/genetics
MH  - Receptors, Virus/*antagonists & inhibitors/genetics
MH  - Swine
MH  - *Virus Internalization
PMC - PMC3719804
EDAT- 2013/06/07 06:00
MHDA- 2013/09/21 06:00
PMCR- 2014/02/01
CRDT- 2013/06/07 06:00
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - JVI.00718-13 [pii]
AID - 00718-13 [pii]
AID - 10.1128/JVI.00718-13 [doi]
PST - ppublish
SO  - J Virol. 2013 Aug;87(15):8808-12. doi: 10.1128/JVI.00718-13. Epub 2013 Jun 5.