PMID- 23741002
OWN - NLM
STAT- MEDLINE
DCOM- 20131018
LR  - 20211021
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 87
IP  - 16
DP  - 2013 Aug
TI  - Susceptibility and pathogenesis of little brown bats (Myotis lucifugus) to 
      heterologous and homologous rabies viruses.
PG  - 9008-15
LID - 10.1128/JVI.03554-12 [doi]
AB  - Rabies virus (RABV) maintenance in bats is not well understood. Big brown bats 
      (Eptesicus fuscus), little brown bats (Myotis lucifugus), and Mexican free-tailed 
      bats (Tadarida brasiliensis) are the most common bats species in the United 
      States. These colonial bat species also have the most frequent contact with 
      humans and domestic animals. However, the silver-haired bat (Lasionycteris 
      noctivagans) RABV is associated with the majority of human rabies virus 
      infections in the United States and Canada. This is of interest because 
      silver-haired bats are more solitary bats with infrequent human interaction. Our 
      goal was to determine the likelihood of a colonial bat species becoming infected 
      with and transmitting a heterologous RABV. To ascertain the potential of 
      heterologous RABV infection in colonial bat species, little brown bats were 
      inoculated with a homologous RABV or one of two heterologous RABVs. Additionally, 
      to determine if the route of exposure influenced the disease process, bats were 
      inoculated either intramuscularly (i.m.) or subcutaneously (s.c.) with a 
      homologous or heterologous RABV. Our results demonstrate that intramuscular 
      inoculation results in a more rapid progression of disease onset, whereas the 
      incubation time in bats inoculated s.c. is significantly longer. Additionally, 
      cross protection was not consistently achieved in bats previously inoculated with 
      a heterologous RABV following a challenge with a homologous RABV 6 months later. 
      Finally, bats that developed rabies following s.c. inoculation were significantly 
      more likely to shed virus in their saliva and demonstrated increased viral 
      dissemination. In summary, bats inoculated via the s.c. route are more likely to 
      shed virus, thus increasing the likelihood of transmission.
FAU - Davis, April D
AU  - Davis AD
AD  - Rabies Laboratory, Wadsworth Center, New York State Department of Health, 
      Slingerlands, New York, USA. add02@health.state.ny.us
FAU - Jarvis, Jodie A
AU  - Jarvis JA
FAU - Pouliott, Craig E
AU  - Pouliott CE
FAU - Morgan, Shannon M D
AU  - Morgan SM
FAU - Rudd, Robert J
AU  - Rudd RJ
LA  - eng
GR  - K08 AI085031/AI/NIAID NIH HHS/United States
GR  - 5K08AI085031/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130605
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
SB  - IM
MH  - Animals
MH  - Chiroptera
MH  - Disease Susceptibility
MH  - Rabies/pathology/transmission/*veterinary/virology
MH  - Rabies virus/immunology/*pathogenicity
MH  - Virus Shedding
PMC - PMC3754046
EDAT- 2013/06/07 06:00
MHDA- 2013/10/19 06:00
PMCR- 2014/02/01
CRDT- 2013/06/07 06:00
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2013/10/19 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - JVI.03554-12 [pii]
AID - 03554-12 [pii]
AID - 10.1128/JVI.03554-12 [doi]
PST - ppublish
SO  - J Virol. 2013 Aug;87(16):9008-15. doi: 10.1128/JVI.03554-12. Epub 2013 Jun 5.