PMID- 23742865
OWN - NLM
STAT- MEDLINE
DCOM- 20140530
LR  - 20131021
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 210
IP  - 1
DP  - 2013 Nov 30
TI  - Association between antidepressant side effects and functional impairment in 
      patients with major depressive disorders.
PG  - 127-33
LID - S0165-1781(13)00265-5 [pii]
LID - 10.1016/j.psychres.2013.05.007 [doi]
AB  - Patients with depression may not well be aware of antidepressant adverse events 
      (AEs); however, no studies have assessed how these AEs affect their daily 
      function. Therefore, to evaluate the relationship between the quality of AEs and 
      functional impairment, we studied 482 outpatients with depressive disorders who 
      were not receiving any antidepressant treatment prior to the baseline visit and 
      started it thereafter in usual clinical settings. The Quick Inventory for 
      Depressive Symptomatology Self-Report Japanese version and antidepressant AEs for 
      subjective assessment (antiAS) were performed at baseline and 10 days after 
      antidepressant initiation (i.e. second visit). Functional impairment was 
      evaluated with the Sheehan Disability Scale (SDS) on the second visit. As a 
      result, the SDS was positively associated with the number of AEs (beta=0.089, 
      p=0.022) in multiple linear regression analysis (adjusted R(2)=0.357, p<0.001). 
      Subjects who experienced vertigo, nausea and insomnia had significantly more 
      functional impairment than those who did not. Additionally, the number of severe 
      AEs (beta=0.151, p<0.001) was associated with a higher SDS score, and those AEs with 
      a negative causal attribution to antidepressants in the antiAS significantly 
      affected the SDS (beta=0.105, p=0.008). AEs of antidepressants should be carefully 
      monitored since they could negatively affect their daily function.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Kikuchi, Toshiaki
AU  - Kikuchi T
AD  - Keio University, School of Medicine, Department of Neuropsychiatry, 35, 
      Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Columbia University, Department 
      of Psychiatry, NY, United States. Electronic address: t-kick@nifty.com.
FAU - Suzuki, Takefumi
AU  - Suzuki T
FAU - Uchida, Hiroyuki
AU  - Uchida H
FAU - Watanabe, Koichiro
AU  - Watanabe K
FAU - Mimura, Masaru
AU  - Mimura M
LA  - eng
PT  - Journal Article
DEP - 20130603
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*adverse effects
MH  - Cognition Disorders/*chemically induced
MH  - Depressive Disorder, Major/drug therapy
MH  - *Disabled Persons
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Memory Disorders/*chemically induced
MH  - Middle Aged
MH  - Nervous System Diseases/*chemically induced
MH  - Outpatients
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Self Report
MH  - Young Adult
OTO - NOTNLM
OT  - Adverse events
OT  - Antidepressant agents
OT  - Daily function
OT  - Depression
OT  - Recognition
OT  - Sheehan Disability Scale
OT  - Underrecognition
EDAT- 2013/06/08 06:00
MHDA- 2014/05/31 06:00
CRDT- 2013/06/08 06:00
PHST- 2012/11/21 00:00 [received]
PHST- 2013/05/06 00:00 [revised]
PHST- 2013/05/09 00:00 [accepted]
PHST- 2013/06/08 06:00 [entrez]
PHST- 2013/06/08 06:00 [pubmed]
PHST- 2014/05/31 06:00 [medline]
AID - S0165-1781(13)00265-5 [pii]
AID - 10.1016/j.psychres.2013.05.007 [doi]
PST - ppublish
SO  - Psychiatry Res. 2013 Nov 30;210(1):127-33. doi: 10.1016/j.psychres.2013.05.007. 
      Epub 2013 Jun 3.