PMID- 23743014
OWN - NLM
STAT- MEDLINE
DCOM- 20130905
LR  - 20130710
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 755
IP  - 1
DP  - 2013 Jul 4
TI  - Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in 
      a radiation accident in Xinzhou, China.
PG  - 68-72
LID - S1383-5718(13)00148-4 [pii]
LID - 10.1016/j.mrgentox.2013.05.015 [doi]
AB  - In November 1992, a radiation accident occurred in Xinzhou, due to the collection 
      by a farmer of an unused (60)Co source; 37 individuals were exposed to ionizing 
      radiation. Three individuals died and the farmer's 19-weeks-pregnant wife 
      suffered acute radiation symptoms. Conventional chromosome analysis, 
      cytokinesis-block micronuclei (CBMN) assay and fluorescence in situ hybridization 
      (FISH) painting with three pairs of whole chromosome probes were used to analyze 
      chromosomal aberrations for the pregnant female and her baby during the 16 years 
      following the accident. The yields of dicentrics and rings (dic+r) continually 
      declined between 41 days and 16 years after the accident. The frequency of 
      binucleated MN also decreased over time for both mother and daughter. Sixteen 
      years after exposure, the yields of dic+r and binucleated MN decreased to normal 
      levels, but the reciprocal translocation frequencies remained elevated, for both 
      mother and daughter. FISH results showed a decreasing yield of translocations 
      with time. Based on the changes in maternal translocation frequency, the 
      daughter's dose at the time of exposure was estimated as 1.82 (1.35-2.54)Gy. This 
      was consistent with the clinical manifestations of severe mental retardation and 
      low IQ score. FISH-based translocation analysis can be used for follow-up studies 
      on accidental exposure and, after correction, for retrospective dose estimation 
      for individuals prenatally exposed to radiation.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Liu, Qing-Jie
AU  - Liu QJ
AD  - National Institute for Radiological Protection, Chinese Center for Disease 
      Control and Prevention, Beijing, People's Republic of China. qjliu@nirp.cn
FAU - Lu, Xue
AU  - Lu X
FAU - Zhao, Hua
AU  - Zhao H
FAU - Chen, Sen
AU  - Chen S
FAU - Wang, Ming-Ming
AU  - Wang MM
FAU - Bai, Yushu
AU  - Bai Y
FAU - Zhang, Shu-Lan
AU  - Zhang SL
FAU - Feng, Jiang-Bin
AU  - Feng JB
FAU - Zhang, Zhao-Hui
AU  - Zhang ZH
FAU - Chen, De-Qing
AU  - Chen DQ
FAU - Ma, Li-Wen
AU  - Ma LW
FAU - Jia, Ting-Zhen
AU  - Jia TZ
FAU - Liang, Li
AU  - Liang L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130603
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - China
MH  - Chromosome Aberrations/*radiation effects
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Fetus/*radiation effects
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Micronucleus Tests
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*diagnosis/etiology
MH  - Radiation Dosage
MH  - Radiation Injuries/*diagnosis/etiology
MH  - Radioactive Hazard Release
MH  - Survivors
OTO - NOTNLM
OT  - Cytogenetic analysis
OT  - Dose estimation
OT  - Fluorescence in situ hybridization
OT  - Prenatal exposure
OT  - Radiation accident
EDAT- 2013/06/08 06:00
MHDA- 2013/09/06 06:00
CRDT- 2013/06/08 06:00
PHST- 2013/03/19 00:00 [received]
PHST- 2013/05/24 00:00 [revised]
PHST- 2013/05/27 00:00 [accepted]
PHST- 2013/06/08 06:00 [entrez]
PHST- 2013/06/08 06:00 [pubmed]
PHST- 2013/09/06 06:00 [medline]
AID - S1383-5718(13)00148-4 [pii]
AID - 10.1016/j.mrgentox.2013.05.015 [doi]
PST - ppublish
SO  - Mutat Res. 2013 Jul 4;755(1):68-72. doi: 10.1016/j.mrgentox.2013.05.015. Epub 
      2013 Jun 3.