PMID- 23743492
OWN - NLM
STAT- MEDLINE
DCOM- 20131105
LR  - 20161125
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 19
IP  - 6
DP  - 2013 Jun
TI  - Endothelial dysfunction is a marker of systemic response to the cardiac 
      resynchronization therapy in heart failure.
PG  - 419-25
LID - S1071-9164(13)00126-7 [pii]
LID - 10.1016/j.cardfail.2013.05.001 [doi]
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) induces a significant 
      improvement in patients with heart failure (HF), who are often characterized by 
      the presence of endothelial dysfunction (ED) with impaired flow-mediated 
      vasodilation (FMD). We aimed to study the ED in patients with HF candidates to 
      CRT with defibrillator (CRT-D). METHODS AND RESULTS: We studied 57 consecutive 
      patients affected by HF and undergoing CRT-D. At the baseline we recorded a high 
      prevalence of ED (64.9%) with impaired FMD (4.1 +/- 3.8%). After 12 months of CRT, 
      we reported a marked increase of the mean FMD (8.8 +/- 4.8% vs 4.1 +/- 3.8%; P < .05) 
      along with significant improvement of left ventricular ejection fraction (LVEF), 
      left ventricular end-systolic volume (LVESV), New York Heart Association (NYHA) 
      functional class, and 6-minute walk test (6MWT); 42 patients (73.7%) were 
      classified as responders according to standard criteria. FMD was related to LVEF 
      (r = 0.169; P < .05), LVESV (r = -0.169; P < .05), NYHA functional class (r = 
      -0.27; P < .051), and 6MWT (r = 0.360; P < .01). CONCLUSIONS: ED is not an 
      independent predictor of CRT response, but it is able to intercept the systemic 
      effects of CRT and is an affordable marker of response to CRT, especially in 
      patients unable to perform the 6MWT.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Santini, Luca
AU  - Santini L
AD  - Department of Cardiology, University Hospital of Tor Vergata, Rome, Italy. 
      lsantini@alice.it
FAU - Capria, Ambrogio
AU  - Capria A
FAU - Di Molfetta, Arianna
AU  - Di Molfetta A
FAU - Mahfouz, Karim
AU  - Mahfouz K
FAU - Panattoni, Germana
AU  - Panattoni G
FAU - Minni, Valentina
AU  - Minni V
FAU - Sergi, Domenico
AU  - Sergi D
FAU - Forleo, Giovanni B
AU  - Forleo GB
FAU - Romeo, Francesco
AU  - Romeo F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - Blood Flow Velocity/physiology
MH  - *Cardiac Resynchronization Therapy
MH  - Cardiac Volume/physiology
MH  - Defibrillators, Implantable
MH  - Endothelium, Vascular/*physiopathology
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Male
MH  - Stroke Volume/physiology
MH  - Ultrasonography
MH  - Vasodilation/physiology
EDAT- 2013/06/08 06:00
MHDA- 2013/11/06 06:00
CRDT- 2013/06/08 06:00
PHST- 2013/01/17 00:00 [received]
PHST- 2013/03/11 00:00 [revised]
PHST- 2013/05/01 00:00 [accepted]
PHST- 2013/06/08 06:00 [entrez]
PHST- 2013/06/08 06:00 [pubmed]
PHST- 2013/11/06 06:00 [medline]
AID - S1071-9164(13)00126-7 [pii]
AID - 10.1016/j.cardfail.2013.05.001 [doi]
PST - ppublish
SO  - J Card Fail. 2013 Jun;19(6):419-25. doi: 10.1016/j.cardfail.2013.05.001.