PMID- 23743808
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20161125
IS  - 1473-5598 (Electronic)
IS  - 0263-6352 (Linking)
VI  - 31
IP  - 8
DP  - 2013 Aug
TI  - Persistent organic pollutants and abnormal geometry of the left ventricle in the 
      elderly.
PG  - 1547-53
LID - 10.1097/HJH.0b013e32836221b3 [doi]
AB  - BACKGROUND: Established risk factors for left ventricular hypertrophy (LVH) are 
      hypertension, diabetes, and obesity. However, as these risk factors explain only 
      part of the variation in left ventricular mass, we investigated whether 
      persistent organic pollutants (POPs) might also play a role in LVH, because 
      exposure to polychlorinated biphenyl 126 induced cardiac growth in rats. METHODS: 
      In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), 
      left ventricular mass index (LVMI), relative wall thickness (RWT), and geometric 
      groups of LVH, were determined by echocardiography and 21 POPs were measured by 
      high-resolution chromatography coupled to high-resolution mass spectrometry 
      (HRGC/HRMS) in 1016 individuals aged 70 years. All individuals with a history of 
      myocardial infarction were excluded from analysis (n = 72). RESULTS: Several of 
      the POPs were related to abnormal left ventricular geometry before adjustment for 
      established risk factors, but lost in significance following adjustment. However, 
      the pesticide hexachlorobenzene (HCB) levels were significantly related to RWT, 
      and concentric left ventricular remodeling, also following adjustment for sex, 
      blood pressure, antihypertensive treatment, diabetes, and BMI (P <0.0001). 
      CONCLUSION: In this cross-sectional study, circulating levels of HCB were related 
      to increased wall thickness of the left ventricle and concentric left ventricular 
      remodeling, independently of LVH risk factors, suggesting a role of this 
      environmental contaminant in abnormal growth of the left ventricle.
FAU - Sjoberg Lind, Ylva
AU  - Sjoberg Lind Y
AD  - Department of Emergency Medicine, Linkoping University Hospital, Linkoping, 
      Sweden.
FAU - Lind, Lars
AU  - Lind L
FAU - Salihovic, Samira
AU  - Salihovic S
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Lind, P Monica
AU  - Lind PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Hypertens
JT  - Journal of hypertension
JID - 8306882
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Antihypertensive Agents/chemistry
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/physiopathology
MH  - Echocardiography
MH  - Echocardiography, Doppler
MH  - Female
MH  - Heart Ventricles/anatomy & histology/diagnostic imaging/*drug effects
MH  - Hexachlorobenzene/chemistry
MH  - Humans
MH  - Male
MH  - Mass Spectrometry
MH  - Organic Chemicals/*chemistry
MH  - Pesticides/chemistry
MH  - Prospective Studies
MH  - Rats
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Sweden
EDAT- 2013/06/08 06:00
MHDA- 2014/02/08 06:00
CRDT- 2013/06/08 06:00
PHST- 2013/06/08 06:00 [entrez]
PHST- 2013/06/08 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
AID - 10.1097/HJH.0b013e32836221b3 [doi]
PST - ppublish
SO  - J Hypertens. 2013 Aug;31(8):1547-53. doi: 10.1097/HJH.0b013e32836221b3.