PMID- 23744399
OWN - NLM
STAT- MEDLINE
DCOM- 20140526
LR  - 20180816
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 45
IP  - 4
DP  - 2013 Oct
TI  - Taurine prevented cell cycle arrest and restored neurotrophic gene expression in 
      arsenite-treated SH-SY5Y cells.
PG  - 811-9
LID - 10.1007/s00726-013-1524-y [doi]
AB  - The study investigated the effect of taurine on cell viability and neurotrophic 
      gene expression in arsenite-treated human neuroblastoma SH-SY5Y cells. 
      Arsenite-induced intracellular reactive oxygen species (ROS) and interrupted cell 
      cycle in SH-SY5Y cells. In addition, arsenite reduced mitochondria membrane 
      potential (MMP) and decreased neurotrophic gene expressions such as n-myc 
      downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) 
      and sirtuin-1 (SIRT-1) in SH-SY5Y cells. In parallel, taurine prevented cell 
      cycle, restored MMP and reduced the intracellular ROS level, and taurine 
      recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y 
      cells while taurine alone has no effect on these parameters.
FAU - Chou, Chien-Te
AU  - Chou CT
AD  - Department of Food Science, National Taiwan Ocean University, 2 Pei-Ning Road, 
      Keelung 202, Taiwan, ROC.
FAU - Lin, Wen-Feng
AU  - Lin WF
FAU - Kong, Zwe-Ling
AU  - Kong ZL
FAU - Chen, Shiow-Yi
AU  - Chen SY
FAU - Hwang, Deng-Fwu
AU  - Hwang DF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130607
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Arsenites)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Muscle Proteins)
RN  - 0 (NDRG4 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Reactive Oxygen Species)
RN  - 1EQV5MLY3D (Taurine)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 3.5.1.- (SIRT1 protein, human)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - N5509X556J (arsenite)
SB  - IM
MH  - Arsenites/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cell Cycle Checkpoints/*drug effects
MH  - Cell Survival/drug effects
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/*drug effects
MH  - Humans
MH  - Membrane Potential, Mitochondrial/drug effects
MH  - Muscle Proteins/*genetics/metabolism
MH  - Nerve Tissue Proteins/*genetics/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Sirtuin 1/*genetics/metabolism
MH  - Taurine/*pharmacology
MH  - Tumor Cells, Cultured
EDAT- 2013/06/08 06:00
MHDA- 2014/05/27 06:00
CRDT- 2013/06/08 06:00
PHST- 2013/03/28 00:00 [received]
PHST- 2013/05/23 00:00 [accepted]
PHST- 2013/06/08 06:00 [entrez]
PHST- 2013/06/08 06:00 [pubmed]
PHST- 2014/05/27 06:00 [medline]
AID - 10.1007/s00726-013-1524-y [doi]
PST - ppublish
SO  - Amino Acids. 2013 Oct;45(4):811-9. doi: 10.1007/s00726-013-1524-y. Epub 2013 Jun 
      7.