PMID- 23745571
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20130610
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 1
DP  - 2013 Jul
TI  - Transmission disequilibrium analysis of 31 type 1 diabetes susceptibility loci in 
      Finnish families.
PG  - 35-42
LID - 10.1111/tan.12143 [doi]
AB  - Currently more than 50 type 1 diabetes (T1D) loci outside the human leukocyte 
      antigen (HLA)-region have been established in large European and/or North 
      American populations. Our aim was to attempt to replicate these findings in the 
      less heterogenic Finnish population and to explore evidence for genetic 
      heterogeneity. We analyzed 1761 Finnish T1D trio families for association in 31 
      T1D loci (25 confirmed and 6 have inconsistent prior evidence). Families were 
      categorized into nine different subgroups according to potential features that 
      reflect underlying genetic heterogeneity in patients (age at diagnosis, sex and 
      HLA genotypes). Seventeen confirmed loci and one nonconfirmed locus (1p31.1) 
      presented significant evidence for association in the full data set. Magnitude 
      and direction of effect was consistent with prior evidence. The strongest effects 
      were seen at the insulin gene, PTPN22 and IL2RA regions. Tentative evidence of 
      odds ratio (OR) heterogeneity within subgroups was seen in eight loci. Our 
      findings were well in line with those reported in the latest meta-analyses using 
      large admixed Caucasian populations, which concurs with the notion that the 
      currently confirmed T1D loci, that have been discovered and replicated mostly in 
      diverse populations, are common to all European populations. The observed effect 
      modifications by subgrouping require validation in later studies with more 
      statistical power.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Laine, A P
AU  - Laine AP
AD  - Immunogenetics Laboratory, University of Turku, Turku, Finland. aplaine@utu.fi
FAU - Knip, M
AU  - Knip M
FAU - Ilonen, J
AU  - Ilonen J
CN  - Finnish Pediatric Diabetes Register
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Databases, Genetic
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Family
MH  - Female
MH  - Finland
MH  - Genetic Loci/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Linkage Disequilibrium/*genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
FIR - Knip, Mikael
IR  - Knip M
FIR - Groop, Per-Henrik
IR  - Groop PH
FIR - Ilonen, Jorma
IR  - Ilonen J
FIR - Lappi, Anneli
IR  - Lappi A
FIR - Otonkoski, Timo
IR  - Otonkoski T
FIR - Saha, Marja-Terrtu
IR  - Saha MT
FIR - Simell, Olli
IR  - Simell O
FIR - Talvitie, Timo
IR  - Talvitie T
FIR - Vaarala, Outi
IR  - Vaarala O
FIR - Veijola, Riitta
IR  - Veijola R
FIR - Aito, Henrikka
IR  - Aito H
FIR - Bondestam, Jonas
IR  - Bondestam J
FIR - Dahllund, Thomas
IR  - Dahllund T
FIR - Granvik, Johanna
IR  - Granvik J
FIR - Haapalehto-Ikonen, Maarit
IR  - Haapalehto-Ikonen M
FIR - Hamalainen, Anu-Maaria
IR  - Hamalainen AM
FIR - Huopio, Hanna
IR  - Huopio H
FIR - Johansson, Christian
IR  - Johansson C
FIR - Kinnala, Anne
IR  - Kinnala A
FIR - Korhonen, Jussi
IR  - Korhonen J
FIR - Korteniemi, Maarit
IR  - Korteniemi M
FIR - Lautala, Pentti
IR  - Lautala P
FIR - Lindstrom, Kaija
IR  - Lindstrom K
FIR - Miettinen, Paivi
IR  - Miettinen P
FIR - Mustila, Taina
IR  - Mustila T
FIR - Nuuja, Anja
IR  - Nuuja A
FIR - Nykanen, Paivi
IR  - Nykanen P
FIR - Ojanpera, Jussi
IR  - Ojanpera J
FIR - Anne-Putto-Laurila
IR  - Anne-Putto-Laurila
FIR - Saha, Marja-Terttu
IR  - Saha MT
FIR - Sankila, Juhani
IR  - Sankila J
FIR - Suomi, Anne-Maarit
IR  - Suomi AM
FIR - Tenhola, Sirpa
IR  - Tenhola S
FIR - Varimo, Pentti
IR  - Varimo P
FIR - Veijola, Riitta
IR  - Veijola R
FIR - Virransalo, Ritva
IR  - Virransalo R
FIR - Vuolukka, Pentti
IR  - Vuolukka P
FIR - Vuorela, Niina
IR  - Vuorela N
FIR - Ylitalo, Samuli
IR  - Ylitalo S
EDAT- 2013/06/12 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/06/11 06:00
PHST- 2013/03/04 00:00 [received]
PHST- 2013/04/23 00:00 [revised]
PHST- 2013/05/17 00:00 [accepted]
PHST- 2013/06/11 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 10.1111/tan.12143 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Jul;82(1):35-42. doi: 10.1111/tan.12143.