PMID- 23745572
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20130610
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 1
DP  - 2013 Jul
TI  - Association of HLA-G 3' untranslated region polymorphisms with antibody response 
      against Plasmodium falciparum antigens: preliminary results.
PG  - 53-8
LID - 10.1111/tan.12140 [doi]
AB  - Host and Plasmodium interactions result in highly variable clinical phenotypes, 
      partly explained by the nature and level of anti-malarial antibody response. 
      Human leukocyte antigen (HLA)-G can create a tolerogenic environment, allowing 
      parasites to escape from anti-malarial immunity. We performed a family-based 
      association study encompassing 483 Sereer individuals (261 children and their 
      parents), and reported two independent signals at the HLA-G 3' untranslated 
      region associated with antibody response to specific Plasmodium falciparum blood 
      stage antigens, previously associated with malaria protection: (i) +3010G 
      together with +3142C with total IgG and IgG1 against GLURP and (ii) +3196G with 
      IgG3 against MSP2. While these results require further investigation, they 
      suggest for the first time a role of HLA-G in the regulation of humoral immune 
      response in malaria.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Sabbagh, A
AU  - Sabbagh A
AD  - Institut de Recherche pour le Developpement, UMR 216 Mere et enfant face aux 
      infections tropicales, Paris, France. audrey.sabbagh@ird.fr
FAU - Courtin, D
AU  - Courtin D
FAU - Milet, J
AU  - Milet J
FAU - Massaro, J D
AU  - Massaro JD
FAU - Castelli, E C
AU  - Castelli EC
FAU - Migot-Nabias, F
AU  - Migot-Nabias F
FAU - Favier, B
AU  - Favier B
FAU - Rouas-Freiss, N
AU  - Rouas-Freiss N
FAU - Moreau, P
AU  - Moreau P
FAU - Garcia, A
AU  - Garcia A
FAU - Donadi, E A
AU  - Donadi EA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - 3' Untranslated Regions/*genetics
MH  - Adolescent
MH  - Antibody Formation/*immunology
MH  - Antigens, Protozoan/*immunology
MH  - Child
MH  - Child, Preschool
MH  - *Genetic Association Studies
MH  - HLA-G Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Malaria, Falciparum/immunology
MH  - Plasmodium falciparum/*immunology
MH  - *Polymorphism, Genetic
MH  - Senegal
EDAT- 2013/06/12 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/06/11 06:00
PHST- 2013/01/22 00:00 [received]
PHST- 2013/04/08 00:00 [revised]
PHST- 2013/05/15 00:00 [accepted]
PHST- 2013/06/11 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 10.1111/tan.12140 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Jul;82(1):53-8. doi: 10.1111/tan.12140.