PMID- 23746240
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20161125
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 29
IP  - 6
DP  - 2013 Jun
TI  - [Expression of endoglin in human non-small cell lung cancer and its clinical 
      significance].
PG  - 581-4
AB  - OBJECTIVE: To investigate the expression of endoglin (ENG) in human non small 
      cell lung cancer (NSCLC) cell lines, cancer and adjacent non-cancer tissues, and 
      its role in NSCLC development, progression, metastasis and recurrence. METHODS: 
      Five strains of NSCLC cells and one strain of normal human bronchial epithelial 
      (HBE) cells were cultured in vitro. Human NSCLC tissues and their corresponding 
      adjacent lung tissues were taken from 22 NSCLC cases to detect the mRNA and 
      protein levels of ENG using real-time PCR and Western blotting, respectively. 
      Chi-square test was performed to analyze the correlations between the ENG 
      expression and clinical data. RESULTS: The mRNA and protein levels of ENG were 
      up-regulated in 3 NSCLC cell strains of high metastasis. However, the expression 
      of ENG was missing in the other low-metastatic NSCLC cell strains and the HBE 
      cell strain. Besides, the mRNA and protein levels of ENG were up-regulated in the 
      19 out of 22 lung cancer tissues (86.36%), which were significantly higher than 
      those in the adjacent non-cancer tissues (P<0.01). The over-expression of ENG was 
      significantly correlated positively with lymph node metastasis (P<0.01), but not 
      with age, sex, tumor size, clinical stage, pathological grade or 
      histopathological type. CONCLUSION: The expression of ENG in NSCLC is 
      significantly correlated positively with lymph node metastasis, and it might be a 
      biomarker for the metastasis and prognosis of NSCLC.
FAU - Li, Mengmeng
AU  - Li M
AD  - Department of Pulmonary Diseases, First Affiliated Hospital, Soochow University, 
      Soochow 215000, China.
FAU - Lu, Shendong
AU  - Lu S
FAU - Liu, Xinxin
AU  - Liu X
FAU - Zhao, Jun
AU  - Zhao J
FAU - Zhang, Hongtao
AU  - Zhang H
FAU - Ling, Chunhua
AU  - Ling C
LA  - chi
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (Antigens, CD)
RN  - 0 (ENG protein, human)
RN  - 0 (Endoglin)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD/*genetics/metabolism
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/metabolism/pathology
MH  - Cell Line
MH  - Endoglin
MH  - Female
MH  - *Gene Expression
MH  - Humans
MH  - Lung Neoplasms/*genetics/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Receptors, Cell Surface/*genetics/metabolism
EDAT- 2013/06/12 06:00
MHDA- 2013/09/14 06:00
CRDT- 2013/06/11 06:00
PHST- 2013/06/11 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Jun;29(6):581-4.