PMID- 23746715
OWN - NLM
STAT- MEDLINE
DCOM- 20131106
LR  - 20161125
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 82
IP  - 2
DP  - 2013 Aug
TI  - ERG protein expression and gene rearrangements are present at lower rates in 
      metastatic and locally advanced castration-resistant prostate cancer compared to 
      localized disease.
PG  - 394-9
LID - S0090-4295(13)00401-9 [pii]
LID - 10.1016/j.urology.2013.03.029 [doi]
AB  - OBJECTIVE: To compare ERG expression and gene rearrangements rates in metastatic 
      and castration-resistant prostate cancer (CRPC) to localized disease as ERG is 
      the most common genetic event in early prostate cancer (PCa) with potential 
      prognostic and therapeutic implications. METHODS: We evaluated ERG protein 
      expression in 344 patients with PCa in 3 cohorts including localized, metastatic, 
      and castration-resistant disease using immunohistochemistry (IHC) and 
      fluorescence in situ hybridization (FISH). RESULTS: ERG protein expression was 
      detected exclusively in the neoplastic epithelium and was found in 6.8% and 46.3% 
      of high-grade prostatic intraepithelial neoplasia (HGPIN) and localized PCa, 
      respectively. In metastatic and locally advanced CRPC, ERG expression was 
      significantly lower, occurring at 36.1% and 37.2%, respectively. In PCa with 
      foamy gland morphology, ERG protein expression was detected in only 18.6% 
      compared with reported rates of about 42%-48% in acinar PCa. Moreover, ERG 
      protein expression and gene rearrangements showed an overall consistency rate of 
      90.6% (P <.0001). The consistency rate was 100% both in benign glands and HGPIN, 
      and 96.1% in localized PCa. However, it was significantly lower at 76.9% and 85% 
      in node metastatic and CRPC, respectively (P <.0001). CONCLUSION: ERG protein 
      expression is restricted to neoplastic prostatic epithelium and is present at 
      lower rates in metastatic and CRPC compared to localized PCa. IHC and FISH 
      concordance rates were significantly lower in node metastatic and CRPC compared 
      to localized PCa, which may suggest different biological and therapeutic 
      implications. The lower rate of ERG protein expression in foamy gland PCa may 
      suggest potential differences for this pattern of PCa at the molecular level.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Teng, Liang-Hong
AU  - Teng LH
AD  - Department of Pathology and Laboratory Medicine, University of Calgary and 
      Calgary Laboratory Services, Calgary, Alberta, Canada.
FAU - Wang, Cheng
AU  - Wang C
FAU - Begin, Louis R
AU  - Begin LR
FAU - Dolph, Michael
AU  - Dolph M
FAU - Yilmaz, Asli
AU  - Yilmaz A
FAU - Trpkov, Kiril
AU  - Trpkov K
FAU - Donnelly, Bryan
AU  - Donnelly B
FAU - Bismar, Tarek A
AU  - Bismar TA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130606
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - 0 (ERG protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcriptional Regulator ERG)
SB  - IM
MH  - Adenocarcinoma/genetics/*metabolism/secondary/surgery
MH  - Chi-Square Distribution
MH  - Epithelial Cells/metabolism
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Neoplasm Grading
MH  - Orchiectomy
MH  - Prostatic Neoplasms/genetics/*metabolism/*pathology/surgery
MH  - Tissue Array Analysis
MH  - Trans-Activators/*genetics/*metabolism
MH  - Transcriptional Regulator ERG
EDAT- 2013/06/12 06:00
MHDA- 2013/11/07 06:00
CRDT- 2013/06/11 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2013/02/20 00:00 [revised]
PHST- 2013/03/09 00:00 [accepted]
PHST- 2013/06/11 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2013/11/07 06:00 [medline]
AID - S0090-4295(13)00401-9 [pii]
AID - 10.1016/j.urology.2013.03.029 [doi]
PST - ppublish
SO  - Urology. 2013 Aug;82(2):394-9. doi: 10.1016/j.urology.2013.03.029. Epub 2013 Jun 
      6.