PMID- 23747813
OWN - NLM
STAT- MEDLINE
DCOM- 20140205
LR  - 20240229
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1523
DP  - 2013 Jul 26
TI  - Puerarin attenuates neuronal degeneration in the substantia nigra of 
      6-OHDA-lesioned rats through regulating BDNF expression and activating the 
      Nrf2/ARE signaling pathway.
PG  - 1-9
LID - S0006-8993(13)00809-3 [pii]
LID - 10.1016/j.brainres.2013.05.046 [doi]
AB  - An increasing number of studies suggest that oxidative stress is associated with 
      the Parkinsonian process. This study evaluated the potential neuroprotective role 
      of puerarin (PR) on lesioned substantia nigra (SN) induced by 6-hydroxydopamine 
      (6-OHDA). Data from a rotational test showed that PR treatment significantly 
      decreased apomorphine-induced rotations. Both the dopamine (DA) content in the SN 
      and the endogenous expression of brain-derived neurotrophic factor (BDNF) were 
      also elevated by the treatment. Pathological examination showed that dopaminergic 
      neuronal degeneration in the SN was attenuated by PR treatment. Meanwhile, the 
      contents of gamma-glutamylcysteine synthetase (gamma-GCS), glutathione (GSH) and catalase 
      (CAT) in SN tissue were gradually elevated. Additionally, cytochrome c oxidase 
      (COX) mRNA expression in the SN was markedly up-regulated. At the same time, 
      nuclear factor E2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 
      (Keapl) levels were progressively increased by the PR treatment. Our findings 
      indicated that puerarin effectively protects against 6-OHDA-mediated oxidative 
      stress injury in SN neurons, in which the underlying mechanisms are involved in 
      modulating BDNF expression and activating the Nrf2/ARE signaling pathway.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Li, Rong
AU  - Li R
AD  - Guilin Medical University, Guilin, Guangxi 541004, PR China.
FAU - Liang, Tao
AU  - Liang T
FAU - Xu, Lingyuan
AU  - Xu L
FAU - Zheng, Ni
AU  - Zheng N
FAU - Zhang, Kefeng
AU  - Zhang K
FAU - Duan, Xiaoqun
AU  - Duan X
LA  - eng
PT  - Journal Article
DEP - 20130605
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 1.11.1.6 (Catalase)
RN  - VTD58H1Z2X (Dopamine)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 6.3.2.2 (Glutamate-Cysteine Ligase)
RN  - GAN16C9B8O (Glutathione)
RN  - 0 (Hydroxydopamines)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Isoflavones)
RN  - 0 (KEAP1 protein, rat)
RN  - 0 (Kelch-Like ECH-Associated Protein 1)
RN  - 0 (Neuroprotective Agents)
RN  - Z9W8997416 (puerarin)
RN  - 0 (Sympatholytics)
RN  - 0 (NF-E2-Related Factor 2)
SB  - IM
MH  - Animals
MH  - Male
MH  - Rats
MH  - *Antioxidants/adverse effects/pharmacology
MH  - Blotting, Western
MH  - *Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Catalase/metabolism
MH  - Dopamine/metabolism
MH  - Electron Transport Complex IV/metabolism
MH  - Glutamate-Cysteine Ligase/metabolism
MH  - Glutathione/metabolism
MH  - Hydroxydopamines
MH  - Immunohistochemistry
MH  - Intracellular Signaling Peptides and Proteins/biosynthesis/genetics
MH  - *Isoflavones/adverse effects/pharmacology
MH  - Kelch-Like ECH-Associated Protein 1
MH  - *Nerve Degeneration/prevention & control
MH  - *Neuroprotective Agents
MH  - Rats, Wistar
MH  - *Signal Transduction/drug effects/physiology
MH  - *Substantia Nigra/cytology/drug effects/physiology
MH  - Sympatholytics
MH  - *NF-E2-Related Factor 2/biosynthesis
OTO - NOTNLM
OT  - BDNF
OT  - Nrf2/ARE signaling pathway
OT  - Oxidative stress
OT  - Parkinson's disease
OT  - Puerarin
OT  - Substantia nigra
EDAT- 2013/06/12 06:00
MHDA- 2014/02/05 06:00
CRDT- 2013/06/11 06:00
PHST- 2013/01/17 00:00 [received]
PHST- 2013/04/13 00:00 [revised]
PHST- 2013/05/28 00:00 [accepted]
PHST- 2013/06/11 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - S0006-8993(13)00809-3 [pii]
AID - 10.1016/j.brainres.2013.05.046 [doi]
PST - ppublish
SO  - Brain Res. 2013 Jul 26;1523:1-9. doi: 10.1016/j.brainres.2013.05.046. Epub 2013 
      Jun 5.