PMID- 23747868
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20220224
IS  - 2768-6698 (Electronic)
IS  - 2768-6698 (Linking)
VI  - 18
IP  - 3
DP  - 2013 Jun 1
TI  - Genetic susceptibility to Grave's disease.
PG  - 1080-7
AB  - The variety of clinical presentations of eye changes in patients with Graves' 
      disease (GD) suggests that complex interactions between genetic, environmental, 
      endogenous and local factors influence the severity of Graves' ophthalmopathy 
      (GO). It is thought that the development of GO might be influenced by genetic 
      factors and environmental factors, such as cigarette smoking. At present, 
      however, the role of genetic factors in the development of GO is not known. On 
      the basis of studies with candidate genes and other genetic approaches, several 
      susceptibility loci in GO have been proposed, including immunological genes, 
      human leukocyte antigen (HLA), cytotoxic T-lymphocyte antigen-4 (CTLA-4), 
      regulatory T-cell genes and thyroid-specific genes. This review gives a brief 
      overview of the current range of major susceptibility genes found for GD.
FAU - Li, Hong
AU  - Li H
AD  - Department of Endocrinology, Long Hua Hospital Affiliated to Shanghai University 
      of Traditional Chinese Medicine, Shanghai,China. shanhongli2012@yeah.net
FAU - Chen, Qiuying
AU  - Chen Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130601
PL  - Singapore
TA  - Front Biosci (Landmark Ed)
JT  - Frontiers in bioscience (Landmark edition)
JID - 101612996
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Graves Disease/*genetics/immunology
MH  - Humans
EDAT- 2013/06/12 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/06/11 06:00
PHST- 2013/06/11 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 4164 [pii]
AID - 10.2741/4164 [doi]
PST - epublish
SO  - Front Biosci (Landmark Ed). 2013 Jun 1;18(3):1080-7. doi: 10.2741/4164.