PMID- 23748193 OWN - NLM STAT- MEDLINE DCOM- 20140609 LR - 20211021 IS - 2040-2058 (Electronic) IS - 1359-6535 (Print) IS - 1359-6535 (Linking) VI - 18 IP - 5 DP - 2013 TI - An association between adiposity and serum levels of macrophage inflammatory protein-1alpha and soluble CD14 in HIV-infected adults: results from a cross-sectional study. PG - 729-33 LID - 10.3851/IMP2645 [doi] AB - BACKGROUND: Greater adipose tissue is associated with increased circulating high-sensitivity C-reactive protein (hsCRP) levels in HIV-infected adults on antiretroviral therapy (ART), but the relationship between adiposity and other inflammation biomarkers is not well-characterized. METHODS: We measured total and regional adipose tissue deposits using dual energy X-ray absorptiometry (DXA) and serum levels of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) receptor 1 and 2, macrophage inflammatory protein-1alpha (MIP-1alpha), macrophage chemotactic protein-1 (MCP-1), soluble CD14 and hsCRP in a cohort of adults on long-term ART. Regression models were adjusted for age, sex, CD4(+) T-cell count, smoking status, protease-inhibitor-use and daily use of either non-steroidal anti-inflammatory drugs or aspirin. RESULTS: The majority (77%) of the 85 study participants were male, median CD4(+) T-cell count was 500 cells/mul (IQR 315-734) and median BMI was 25.1 kg/m(2) (IQR 22.7-28.1). DXA measurements of total fat mass were positively associated with serum hsCRP (beta=1.82, P<0.01) and MIP-1alpha (beta=1.36, P<0.01), but negatively associated with soluble CD14 (beta=0.90, P<0.01). Results were similar for trunk fat, limb fat and serum leptin level. The positive relationship between DXA measurements and TNF-alpha receptor 1 approached significance (P