PMID- 23749635
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20211021
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 191
IP  - 2
DP  - 2013 Jul 15
TI  - SARM is required for neuronal injury and cytokine production in response to 
      central nervous system viral infection.
PG  - 875-83
LID - 10.4049/jimmunol.1300374 [doi]
AB  - Four of the five members of the Toll/IL-1R domain-containing adaptor family are 
      required for signaling downstream of TLRs, promoting innate immune responses 
      against different pathogens. However, the role of the fifth member of this 
      family, sterile alpha and Toll/IL-1R domain-containing 1 (SARM), is unclear. SARM is 
      expressed primarily in the CNS where it is required for axonal death. Studies in 
      Caenorhabditis elegans have also shown a role for SARM in innate immunity. To 
      clarify the role of mammalian SARM in innate immunity, we infected SARM(-/-) mice 
      with a number of bacterial and viral pathogens. SARM(-/-) mice show normal 
      responses to Listeria monocytogenes, Mycobacterium tuberculosis, and influenza 
      virus, but show dramatic protection from death after CNS infection with vesicular 
      stomatitis virus. Protection correlates with reduced CNS injury and cytokine 
      production by nonhematopoietic cells, suggesting that SARM is a positive 
      regulator of cytokine production. Neurons and microglia are the predominant 
      source of cytokines in vivo, supporting a role for SARM as a link between 
      neuronal injury and innate immunity.
FAU - Hou, Ying-Ju
AU  - Hou YJ
AD  - Department of Microbiology and Immunology, Weill Medical College of Cornell 
      University, New York, NY 10021, USA.
FAU - Banerjee, Rebecca
AU  - Banerjee R
FAU - Thomas, Bobby
AU  - Thomas B
FAU - Nathan, Carl
AU  - Nathan C
FAU - Garcia-Sastre, Adolfo
AU  - Garcia-Sastre A
FAU - Ding, Aihao
AU  - Ding A
FAU - Uccellini, Melissa B
AU  - Uccellini MB
LA  - eng
SI  - GEO/GSE44331
GR  - R01 NS060885/NS/NINDS NIH HHS/United States
GR  - U19 AI083025/AI/NIAID NIH HHS/United States
GR  - U19AI083025/AI/NIAID NIH HHS/United States
GR  - NS060885/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130607
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Armadillo Domain Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (SARM1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Armadillo Domain Proteins/genetics/immunology/*metabolism
MH  - Bone Marrow Cells
MH  - Cells, Cultured
MH  - Central Nervous System/metabolism/microbiology/virology
MH  - Central Nervous System Viral Diseases/*immunology/metabolism
MH  - Cytokines/biosynthesis
MH  - Cytoskeletal Proteins/genetics/immunology/*metabolism
MH  - Immunity, Innate
MH  - Influenza A virus/immunology
MH  - Listeria monocytogenes/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Microglia/metabolism
MH  - Mycobacterium tuberculosis/immunology
MH  - Neurons/metabolism
MH  - Rhabdoviridae Infections/*immunology/metabolism
MH  - Vesicular stomatitis Indiana virus/*immunology
PMC - PMC3710687
MID - NIHMS485090
EDAT- 2013/06/12 06:00
MHDA- 2013/09/21 06:00
PMCR- 2014/07/15
CRDT- 2013/06/11 06:00
PHST- 2013/06/11 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2014/07/15 00:00 [pmc-release]
AID - jimmunol.1300374 [pii]
AID - 10.4049/jimmunol.1300374 [doi]
PST - ppublish
SO  - J Immunol. 2013 Jul 15;191(2):875-83. doi: 10.4049/jimmunol.1300374. Epub 2013 
      Jun 7.