PMID- 23750159
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130611
LR  - 20240322
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 4
DP  - 2013
TI  - Immunogenetics: Genome-Wide Association of Non-Progressive HIV and Viral Load 
      Control: HLA Genes and Beyond.
PG  - 118
LID - 10.3389/fimmu.2013.00118 [doi]
LID - 118
AB  - Very early after the identification of the human immunodeficiency virus (HIV), 
      host genetics factors were anticipated to play a role in viral control and 
      disease progression. As early as the mid-1990s, candidate gene studies 
      demonstrated a central role for the chemokine co-receptor/ligand (e.g., CCR5) and 
      human leukocyte antigen (HLA) systems. In the last decade, the advent of 
      genome-wide arrays opened a new era for unbiased genetic exploration of the 
      genome and brought big expectations for the identification of new unexpected 
      genes and pathways involved in HIV/AIDS. More than 15 genome-wide association 
      studies targeting various HIV-linked phenotypes have been published since 2007. 
      Surprisingly, only the two HIV-chemokine co-receptors and HLA loci have exhibited 
      consistent and reproducible statistically significant genetic associations. In 
      this chapter, we will review the findings from the genome-wide studies focusing 
      especially on non-progressive and HIV control phenotypes, and discuss the current 
      perspectives.
FAU - Limou, Sophie
AU  - Limou S
AD  - Basic Science Program, Basic Research Laboratory, Frederick National Laboratory 
      for Cancer Research Frederick, MD, USA.
FAU - Zagury, Jean-Francois
AU  - Zagury JF
LA  - eng
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20130527
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3664380
OTO - NOTNLM
OT  - HIV-1
OT  - HLA
OT  - SNP
OT  - chemokine receptors region
OT  - genome-wide association study
OT  - long-term non-progression
OT  - viral control
EDAT- 2013/06/12 06:00
MHDA- 2013/06/12 06:01
PMCR- 2013/01/01
CRDT- 2013/06/11 06:00
PHST- 2013/03/25 00:00 [received]
PHST- 2013/05/04 00:00 [accepted]
PHST- 2013/06/11 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2013/06/12 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2013.00118 [doi]
PST - epublish
SO  - Front Immunol. 2013 May 27;4:118. doi: 10.3389/fimmu.2013.00118. eCollection 
      2013.