PMID- 23751022
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20211021
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Print)
IS  - 1752-8054 (Linking)
VI  - 6
IP  - 3
DP  - 2013 Jun
TI  - Clinical significance of vimentin expression and Her-2 status in patients with 
      gastric carcinoma.
PG  - 184-90
LID - 10.1111/cts.12043 [doi]
AB  - OBJECTIVES: To determine whether vimentin could be used as a marker of gastric 
      carcinomas with more aggressive behavior. To detect the extent of Her-2 status in 
      gastric carcinoma and explore the correlation between vimentin expression and 
      Her-2 status. METHODS: Vimentin expression was detected in surgically resected 
      gastric carcinoma tissue specimens from 143 patients by immunohistochemistry. The 
      human epidermal growth factor receptor 2 (Her2) status was evaluated by 
      fluorescence in situ hybridization (FISH). Correlations between vimentin 
      expression, Her-2 status and clinicopathological factors were evaluated using 
      Kaplan-Meier method and Cox multivariate survival models. RESULTS: Vimentin 
      expression was significantly correlated with age, advanced stage, poorly 
      differentiated type, venous invasion, hepatic metastasis, and recurrence (p < 
      0.05). Her-2 gene was amplified in 16 (11.2%) out of the 143 gastric carcinoma 
      tissue specimens. Her-2 status was correlated with advanced cancer, poor 
      differentiation, venous invasion, hepatic metastasis, and recurrence (p < 0.05). 
      The result of multivariate analysis showed that vimentin expression and lymph 
      node metastasis were independent prognostic factors. CONCLUSIONS: Vimentin 
      expression in epithelial cells of the surgically resected gastric adenocarcinoma 
      tissue is an independent predictor of short survival, and Her-2 status shows a 
      valuable correlation with clinical parameters.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Zhao, Wenwen
AU  - Zhao W
AD  - Department of Oncology, Affiliated Hospital of Medical College, Qingdao 
      University, Qingdao, 266003, China.
FAU - Yue, Lu
AU  - Yue L
FAU - Zhou, Fang
AU  - Zhou F
FAU - Xu, Congcong
AU  - Xu C
FAU - Liang, Wanhua
AU  - Liang W
FAU - Sui, Aihua
AU  - Sui A
FAU - Ding, Aiping
AU  - Ding A
FAU - Qiu, Wensheng
AU  - Qiu W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130419
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
RN  - 0 (Vimentin)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cytoplasm/metabolism/pathology
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Lymphatic Metastasis/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Receptor, ErbB-2/genetics/*metabolism
MH  - Stomach Neoplasms/genetics/*metabolism/pathology
MH  - Survival Analysis
MH  - Vimentin/*metabolism
PMC - PMC5350850
EDAT- 2013/06/12 06:00
MHDA- 2014/01/24 06:00
PMCR- 2013/06/01
CRDT- 2013/06/12 06:00
PHST- 2013/06/12 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - CTS12043 [pii]
AID - 10.1111/cts.12043 [doi]
PST - ppublish
SO  - Clin Transl Sci. 2013 Jun;6(3):184-90. doi: 10.1111/cts.12043. Epub 2013 Apr 19.