PMID- 23751188
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20130722
IS  - 1878-5875 (Electronic)
IS  - 1357-2725 (Linking)
VI  - 45
IP  - 8
DP  - 2013 Aug
TI  - Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem 
      cells to adipocytes and smooth muscle-like cells.
PG  - 1825-32
LID - S1357-2725(13)00185-4 [pii]
LID - 10.1016/j.biocel.2013.06.003 [doi]
AB  - Early growth response 2 (Egr2) is a zinc-finger transcription factor that acts as 
      an important modulator of a variety of physiological processes, such as cell 
      differentiation, proliferation and apoptosis. Here we showed that Egr2 was 
      downregulated by bone morphogenetic protein (BMP) signaling pathways during the 
      commitment of C3H10T1/2 stem cells to adipocyte lineage. Overexpression of Egr2 
      completely prevented BMP4-induced adipocyte lineage commitment of C3H10T1/2 stem 
      cells, while simultaneously stimulating early smooth muscle-like differentiation. 
      We also demonstrated that Egr2-induced early smooth muscle-like differentiation 
      is transforming growth factor beta1-independent. Egr2 can activate the transcription 
      of early smooth muscle cell specific genes smooth muscle protein 22alpha and calponin 
      1. Together, the results indicated a novel role for Egr2 in repressing adipocyte 
      lineage commitment and promoting early smooth muscle-like cell differentiation.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Wang, Shan-Shan
AU  - Wang SS
AD  - Key Laboratory of Molecular Medicine, The Ministry of Education, Department of 
      Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, 
      Shanghai 200032, PR China.
FAU - Huang, Hai-Yan
AU  - Huang HY
FAU - Chen, Su-Zhen
AU  - Chen SZ
FAU - Li, Xi
AU  - Li X
FAU - Liu, Yang
AU  - Liu Y
FAU - Zhang, Wen-Ting
AU  - Zhang WT
FAU - Tang, Qi-Qun
AU  - Tang QQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130608
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - 0 (Bone Morphogenetic Protein 4)
RN  - 0 (Early Growth Response Protein 2)
RN  - 0 (Egr2 protein, mouse)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adipocytes/*cytology/drug effects/metabolism
MH  - Animals
MH  - Bone Morphogenetic Protein 4/pharmacology
MH  - Cell Differentiation/drug effects/genetics
MH  - *Cell Lineage/drug effects/genetics
MH  - Down-Regulation/drug effects/genetics
MH  - Early Growth Response Protein 2/genetics/*metabolism
MH  - Mice
MH  - Myocytes, Smooth Muscle/*cytology/drug effects/metabolism
MH  - Stem Cells/cytology/drug effects/metabolism
MH  - Transcription, Genetic/drug effects
MH  - Transforming Growth Factor beta1/metabolism
OTO - NOTNLM
OT  - 422/aP2
OT  - Adipogenesis
OT  - BMP4
OT  - C3H10T1/2
OT  - Cnn1
OT  - Commitment
OT  - Egr1
OT  - Egr2
OT  - MSC
OT  - Myocd
OT  - PPARgamma
OT  - SMC
OT  - Sm22alpha
OT  - Sm22beta
OT  - Smooth muscle cell
OT  - Srf
OT  - Tgfbeta1
OT  - actin alpha 2 smooth muscle aorta
OT  - bone morphogenetic protein 4
OT  - calponin 1
OT  - early growth response 1
OT  - early growth response 2
OT  - fatty acid-binding protein
OT  - mesenchymal stem cell
OT  - myocardin
OT  - peroxisome proliferator-activated receptors gamma
OT  - serum response factor
OT  - smooth muscle cell
OT  - smooth muscle protein 22alpha
OT  - smooth muscle protein 22beta
OT  - transforming growth factor beta1
OT  - alpha-SMA
EDAT- 2013/06/12 06:00
MHDA- 2014/02/12 06:00
CRDT- 2013/06/12 06:00
PHST- 2013/03/04 00:00 [received]
PHST- 2013/05/27 00:00 [revised]
PHST- 2013/06/02 00:00 [accepted]
PHST- 2013/06/12 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - S1357-2725(13)00185-4 [pii]
AID - 10.1016/j.biocel.2013.06.003 [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 2013 Aug;45(8):1825-32. doi: 
      10.1016/j.biocel.2013.06.003. Epub 2013 Jun 8.