PMID- 23754185
OWN - NLM
STAT- MEDLINE
DCOM- 20140429
LR  - 20211021
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 36
IP  - 9
DP  - 2013 Sep
TI  - The prognostic significance of narrow fragmented QRS on admission 
      electrocardiogram in patients hospitalized for decompensated systolic heart 
      failure.
PG  - 560-4
LID - 10.1002/clc.22158 [doi]
AB  - BACKGROUND: Narrow fragmented QRS (fQRS) has recently been recognized as a 
      significant predictor of prognosis in various cardiovascular diseases. 
      HYPOTHESIS: We hypothesized that the presence of narrow fQRS on admission 
      electrocardiogram (ECG) in patients with decompensated systolic heart failure 
      (HF) of any cause would be associated with long-term prognosis. METHODS: Patients 
      hospitalized for decompensated HF due to ischemic or nonischemic dilated 
      cardiomyopathy (left ventricular ejection fraction <35%) were retrospectively 
      analyzed. The primary clinical end points were cardiovascular mortality, sudden 
      cardiac death, and rehospitalization for HF. RESULTS: The mean duration of 
      follow-up was 3.73 +/- 1.41 years. Patients were classified as fQRS(+) group 
      (n = 114; mean age, 63.49 +/- 12.04 years) and fQRS(-) group (n = 113 patients; 
      mean age, 65.04 +/- 11.95 years). fQRS on ECG was significantly correlated with New 
      York Heart Association (NYHA) functional class (P = 0.001). In multivariate Cox 
      proportional hazard analysis, narrow fQRS (odds ratio [OR]: 3.130, 95% confidence 
      interval [CI]: 1.560-2.848, P = 0.001), chronic renal failure (OR: 2.455, 95% CI: 
      1.120-5.381, P = 0.025), NYHA class (OR: 8.305, 95% CI: 2.568-26.855, 
      P < 0.0001), and hypoalbuminemia (OR: 2.099, 95% CI: 1.122-3.926, P = 0.020) were 
      independent predictors of cardiovascular mortality. In Kaplan-Meier survival 
      analysis, narrow fQRS on admission ECG predicted worse survival rate at 
      84 months; survival probability significantly decreased in the fQRS(+) group 
      compared with fQRS(-) group (P < 0.0001). CONCLUSIONS: Presence of narrow fQRS is 
      associated with worse NYHA functional class in patients hospitalized for 
      decompensated HF. Narrow fQRS predicts cardiovascular mortality in a specific 
      subgroup of systolic HF patients, namely those hospitalized for decompensated HF 
      of both ischemic and nonischemic causes.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Ozcan, Sevgi
AU  - Ozcan S
AD  - Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Cakmak, Huseyin Altug
AU  - Cakmak HA
FAU - Ikitimur, Baris
AU  - Ikitimur B
FAU - Yurtseven, Ece
AU  - Yurtseven E
FAU - Stavileci, Berna
AU  - Stavileci B
FAU - Tufekcioglu, Ebru Yucel
AU  - Tufekcioglu EY
FAU - Enar, Rasim
AU  - Enar R
LA  - eng
PT  - Journal Article
DEP - 20130610
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Aged
MH  - Disease Progression
MH  - *Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure, Systolic/diagnosis/mortality/*physiopathology
MH  - Humans
MH  - *Inpatients
MH  - Male
MH  - Middle Aged
MH  - *Patient Admission
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate/trends
MH  - Time Factors
MH  - Turkey/epidemiology
PMC - PMC6649522
EDAT- 2013/06/12 06:00
MHDA- 2014/04/30 06:00
PMCR- 2013/06/10
CRDT- 2013/06/12 06:00
PHST- 2013/04/17 00:00 [received]
PHST- 2013/05/07 00:00 [revised]
PHST- 2013/06/12 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2014/04/30 06:00 [medline]
PHST- 2013/06/10 00:00 [pmc-release]
AID - CLC22158 [pii]
AID - 10.1002/clc.22158 [doi]
PST - ppublish
SO  - Clin Cardiol. 2013 Sep;36(9):560-4. doi: 10.1002/clc.22158. Epub 2013 Jun 10.