PMID- 23754870
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20240413
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Print)
IS  - 1176-9106 (Linking)
VI  - 8
DP  - 2013
TI  - A comparison of three multidimensional indices of COPD severity as predictors of 
      future exacerbations.
PG  - 259-71
LID - 10.2147/COPD.S42769 [doi]
AB  - BACKGROUND: Prediction of future exacerbations of chronic obstructive pulmonary 
      disease (COPD) is a major concern for long-term management of this disease. AIM: 
      To determine which of three multidimensional assessment systems (the body mass 
      index, obstruction, dyspnea, and exercise capacity [BODE] index; dyspnea, 
      obstruction, smoking, exacerbations [DOSE] index; or age, dyspnea, obstruction 
      [ADO] index) is superior for predicting exacerbations. METHODS: This was a 2-year 
      prospective cohort study of COPD patients. Pulmonary function tests, the 6-minute 
      walk distance (6MWD), Modified Medical Respiratory Council (MMRC) dyspnea scores, 
      chest computed-tomography measurements, and body composition were analyzed, and 
      predictions of exacerbation by the three assessment systems were compared. 
      RESULTS: Among 183 patients who completed the study, the mean annual exacerbation 
      rate was 0.57 events per patient year, which correlated significantly with lower 
      predicted forced expiratory volume in 1 second (FEV1) (P < 0.001), lower transfer 
      coefficient of the lung for carbon monoxide (%DLco/VA) (P = 0.021), lesser 6MWD 
      (P = 0.016), higher MMRC dyspnea score (P = 0.001), higher DOSE index (P < 
      0.001), higher BODE index (P = 0.001), higher ADO index (P = 0.001), and greater 
      extent of emphysema (P = 0.002). For prediction of exacerbation, the areas under 
      the curves were larger for the DOSE index than for the BODE and ADO indices (P < 
      0.001). Adjusted multiple logistic regression identified the DOSE index as a 
      significant predictor of risk of COPD exacerbation. CONCLUSION: In this study, 
      the DOSE index was a better predictor of exacerbations of COPD when compared with 
      the BODE and ADO indices.
FAU - Motegi, Takashi
AU  - Motegi T
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, Nippon Medical 
      School, Tokyo, Japan. mo-dr@nms.ac.jp
FAU - Jones, Rupert C
AU  - Jones RC
FAU - Ishii, Takeo
AU  - Ishii T
FAU - Hattori, Kumiko
AU  - Hattori K
FAU - Kusunoki, Yuji
AU  - Kusunoki Y
FAU - Furutate, Ryuko
AU  - Furutate R
FAU - Yamada, Kouich
AU  - Yamada K
FAU - Gemma, Akihiko
AU  - Gemma A
FAU - Kida, Kozui
AU  - Kida K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130531
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
SB  - IM
CIN - Int J Chron Obstruct Pulmon Dis. 2013;8:533-5. doi: 10.2147/COPD.S53318. PMID: 
      24235823
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Airway Obstruction/physiopathology
MH  - Cohort Studies
MH  - *Disease Progression
MH  - Dyspnea/physiopathology
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Japan
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Outpatients/statistics & numerical data
MH  - Prognosis
MH  - *Pulmonary Disease, Chronic Obstructive/diagnosis/physiopathology/psychology
MH  - Risk Assessment/*methods
MH  - *Severity of Illness Index
MH  - Smoking/adverse effects
PMC - PMC3674751
OTO - NOTNLM
OT  - BODE index
OT  - DOSE index
OT  - frequency of exacerbation
OT  - multidimensional assessment systems
EDAT- 2013/06/12 06:00
MHDA- 2013/11/08 06:00
PMCR- 2013/05/31
CRDT- 2013/06/12 06:00
PHST- 2013/06/12 06:00 [entrez]
PHST- 2013/06/12 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
PHST- 2013/05/31 00:00 [pmc-release]
AID - copd-8-259 [pii]
AID - 10.2147/COPD.S42769 [doi]
PST - ppublish
SO  - Int J Chron Obstruct Pulmon Dis. 2013;8:259-71. doi: 10.2147/COPD.S42769. Epub 
      2013 May 31.