PMID- 23755948
OWN - NLM
STAT- MEDLINE
DCOM- 20131128
LR  - 20211021
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 100
IP  - 3
DP  - 2013 Sep
TI  - Adipokines, adiposity, and vasomotor symptoms during the menopause transition: 
      findings from the Study of Women's Health Across the Nation.
PG  - 793-800
LID - S0015-0282(13)00568-2 [pii]
LID - 10.1016/j.fertnstert.2013.05.005 [doi]
AB  - OBJECTIVE: To test relationships between adipokines, adiposity, and vasomotor 
      symptoms (VMS), including how these associations vary by menopause stage. DESIGN: 
      A subcohort of the longitudinal cohort Study of Women's Health Across the Nation 
      completed questionnaires, physical measures, and a fasting blood draw annually 
      for 8 years. Associations between a poorer adipokine profile (lower adiponectin, 
      lower high-molecular-weight [HMW] adiponectin, higher leptin, lower soluble 
      leptin receptor, higher monocyte chemoattractant protein 1 [MCP-1]) and VMS were 
      tested with the use of generalized estimating equations adjusting for potential 
      confounders. Interactions by menopause stage (pre-/early perimenopause, late 
      peri-/postmenopause) were tested. SETTING: Community. PATIENT(S): A total of 536 
      women ages 42-52 at baseline. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S) VMS 
      RESULT(S): Associations between adipokines and hot flashes varied by menopause 
      stage, with a poorer adipokine profile associated with higher odds of hot flashes 
      early in the transition (adiponectin(log): odds ratio [OR] 0.68, 95% confidence 
      interval [CI] 0.51-0.90; HMW adiponectin(log): OR 0.70, 95% CI 0.58-0.85; 
      leptin(log): OR 1.23, 95% CI 0.99-1.54; multivariable models including body mass 
      index [BMI]), but not later in the transition. The direction of associations 
      between BMI and VMS also varied by menopausal stage. Higher MCP-1 was associated 
      with more night sweats (OR 1.37, 95% CI 1.06-1.76) across menopausal stages. 
      CONCLUSION(S): An adverse adipokine profile was associated with more VMS, 
      particularly early in the menopause transition.
CI  - Copyright (c) 2013 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Thurston, Rebecca C
AU  - Thurston RC
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 
      USA. thurstonrc@upmc.edu
FAU - Chang, Yuefang
AU  - Chang Y
FAU - Mancuso, Peter
AU  - Mancuso P
FAU - Matthews, Karen A
AU  - Matthews KA
LA  - eng
GR  - HL086858/HL/NHLBI NIH HHS/United States
GR  - U01AG012535/AG/NIA NIH HHS/United States
GR  - U01AG012546/AG/NIA NIH HHS/United States
GR  - U01AG012495/AG/NIA NIH HHS/United States
GR  - AG029216/AG/NIA NIH HHS/United States
GR  - U01AG012531/AG/NIA NIH HHS/United States
GR  - U01AG012505/AG/NIA NIH HHS/United States
GR  - U01 AG012495/AG/NIA NIH HHS/United States
GR  - U01 AG012505/AG/NIA NIH HHS/United States
GR  - U01NR004061/NR/NINR NIH HHS/United States
GR  - U01AG012553/AG/NIA NIH HHS/United States
GR  - U01 AG012554/AG/NIA NIH HHS/United States
GR  - R01 HL086858/HL/NHLBI NIH HHS/United States
GR  - K23 AG029216/AG/NIA NIH HHS/United States
GR  - U01AG012539/AG/NIA NIH HHS/United States
GR  - U01 AG012535/AG/NIA NIH HHS/United States
GR  - U01 AG012553/AG/NIA NIH HHS/United States
GR  - U01 NR004061/NR/NINR NIH HHS/United States
GR  - U01 AG012539/AG/NIA NIH HHS/United States
GR  - U01AG012554/AG/NIA NIH HHS/United States
GR  - U01 AG012546/AG/NIA NIH HHS/United States
GR  - U01 AG012531/AG/NIA NIH HHS/United States
GR  - U01 AG017719/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130610
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Adipokines)
RN  - 0 (Hormones)
SB  - IM
MH  - Adipokines/*blood
MH  - Adiposity/*physiology
MH  - Adult
MH  - Autonomic Nervous System Diseases/blood/epidemiology/*etiology
MH  - Female
MH  - Hormones/blood
MH  - Hot Flashes/blood/epidemiology/etiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Menopause/*blood/*physiology
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - United States/epidemiology
MH  - Vasomotor System/*physiology
MH  - Women's Health/statistics & numerical data
PMC - PMC3759568
MID - NIHMS491445
OTO - NOTNLM
OT  - Adipokines
OT  - adiposity
OT  - hot flashes
OT  - vasomotor symptoms
COIS- The authors have no conflicts of interest.
EDAT- 2013/06/13 06:00
MHDA- 2013/12/16 06:00
PMCR- 2014/09/01
CRDT- 2013/06/13 06:00
PHST- 2013/03/08 00:00 [received]
PHST- 2013/05/02 00:00 [revised]
PHST- 2013/05/03 00:00 [accepted]
PHST- 2013/06/13 06:00 [entrez]
PHST- 2013/06/13 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - S0015-0282(13)00568-2 [pii]
AID - 10.1016/j.fertnstert.2013.05.005 [doi]
PST - ppublish
SO  - Fertil Steril. 2013 Sep;100(3):793-800. doi: 10.1016/j.fertnstert.2013.05.005. 
      Epub 2013 Jun 10.