PMID- 23756160
OWN - NLM
STAT- MEDLINE
DCOM- 20140324
LR  - 20171116
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 9
DP  - 2013 Sep
TI  - Defective expression and function of the ILT2/CD85j regulatory receptor in 
      dendritic cells from patients with systemic lupus erythematosus.
PG  - 1088-96
LID - S0198-8859(13)00147-X [pii]
LID - 10.1016/j.humimm.2013.05.006 [doi]
AB  - Dendritic cells (DCs) play an important role in inducing immune tolerance. 
      Inhibitory receptors, such as ILT2/CD85j, are involved in the tolerogenic effect 
      of DCs and previous studies have indicated the important role of these receptors 
      on the pathogenesis of autoimmune diseases. The aim of this study was to evaluate 
      the expression and function of ILT2 in DCs from SLE patients. Peripheral blood 
      from fifty patients with SLE and 38 healthy volunteers was obtained. ILT2 
      expression was assessed by flow cytometry. DCs were generated in the absence or 
      presence of an anti-ILT2 antibody. The effect of ILT2 in the immunogenic ability 
      of SLE DCs was also evaluated. We observed that SLE patients had significant 
      higher levels of circulating plasmacytoid DCs (pDCs), and that these levels 
      correlated with disease activity. In contrast, the expression of ILT2 was 
      diminished in both pDCs and myeloid DCs (mDCs) from these patients. However, 
      under our experimental conditions, the in vitro differentiation of DCs was not 
      apparently affected by ILT2 engagement. In contrast, the immunogenic capability 
      of monocyte-derived DCs was not down-regulated by ILT2 cross-linking in a 
      significant proportion of SLE patients. Our results suggest that ILT2 
      participates in the defective immune-regulation observed in patients with SLE.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Monsivais-Urenda, Adriana
AU  - Monsivais-Urenda A
AD  - Departamento de Inmunologia y Reumatologia, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran, Mexico, DF, Mexico.
FAU - Gomez-Martin, Diana
AU  - Gomez-Martin D
FAU - Santana-de-Anda, Karina
AU  - Santana-de-Anda K
FAU - Cruz-Martinez, Jose
AU  - Cruz-Martinez J
FAU - Alcocer-Varela, Jorge
AU  - Alcocer-Varela J
FAU - Gonzalez-Amaro, Roberto
AU  - Gonzalez-Amaro R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130610
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, CD)
RN  - 0 (LILRB1 protein, human)
RN  - 0 (Leukocyte Immunoglobulin-like Receptor B1)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*metabolism
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immune Tolerance
MH  - Leukocyte Immunoglobulin-like Receptor B1
MH  - Lupus Erythematosus, Systemic/*immunology
MH  - Male
MH  - Middle Aged
MH  - Myeloid Cells/*immunology
MH  - Receptors, Immunologic/*metabolism
MH  - Young Adult
EDAT- 2013/06/13 06:00
MHDA- 2014/03/25 06:00
CRDT- 2013/06/13 06:00
PHST- 2012/10/20 00:00 [received]
PHST- 2013/05/06 00:00 [revised]
PHST- 2013/05/29 00:00 [accepted]
PHST- 2013/06/13 06:00 [entrez]
PHST- 2013/06/13 06:00 [pubmed]
PHST- 2014/03/25 06:00 [medline]
AID - S0198-8859(13)00147-X [pii]
AID - 10.1016/j.humimm.2013.05.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 Sep;74(9):1088-96. doi: 10.1016/j.humimm.2013.05.006. Epub 2013 
      Jun 10.