PMID- 2375633
OWN - NLM
STAT- MEDLINE
DCOM- 19900824
LR  - 20220228
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 28
IP  - 1
DP  - 1990 Jul
TI  - Nationwide survey of HTLV-I-associated myelopathy in Japan: association with 
      blood transfusion.
PG  - 50-6
AB  - To study the epidemiology of human T-cell lymphotropic virus type I 
      (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Japan, 
      we conducted two nationwide surveys between October 1986 and March 1989. A total 
      of 710 patients with HAM (definite HAM, 589; probable HAM, 121) were reported. Of 
      the 589 patients with definite HAM, 69% were residents of the areas with the 
      highest prevalence HTLV-I in Japan. To determine the importance of blood 
      transfusion in the pathogenesis of HAM/TSP, we performed a case-control study in 
      the Kagoshima district in southern Japan. Significantly more patients with HAM 
      reported a history of blood transfusion (26/129, or 20%) than did subjects in a 
      health survey of the general population (41/1,290, or 3%; odds ratio = 7.7, p 
      less than 0.001) or than did hospitalized neurological patients (6/119, or 5%; 
      odds ratio = 4.8, p less than 0.001). Furthermore, the cumulative percentages of 
      the intervals between blood transfusion and the onset of the symptoms of HAM fit 
      a lognormal curve, suggesting that transfusion was an important common exposure. 
      Blood transfusion probably transmitted HTLV-I to the patients with 
      transfusion-associated HAM because there was a significant decrease in the number 
      of patients with the transfusion-associated HAM who received blood after 
      implementation of nationwide screening of blood donors in 1986 (p = 0.004). In 
      the first 2 years, screening the blood supply in Japan appears to have decreased 
      the number of reported patients with HAM by 16%.
FAU - Osame, M
AU  - Osame M
AD  - Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 
      Japan.
FAU - Janssen, R
AU  - Janssen R
FAU - Kubota, H
AU  - Kubota H
FAU - Nishitani, H
AU  - Nishitani H
FAU - Igata, A
AU  - Igata A
FAU - Nagataki, S
AU  - Nagataki S
FAU - Mori, M
AU  - Mori M
FAU - Goto, I
AU  - Goto I
FAU - Shimabukuro, H
AU  - Shimabukuro H
FAU - Khabbaz, R
AU  - Khabbaz R
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
SB  - IM
MH  - Humans
MH  - Japan/epidemiology
MH  - Paraparesis, Tropical Spastic/*epidemiology/etiology
MH  - *Transfusion Reaction
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
AID - 10.1002/ana.410280110 [doi]
PST - ppublish
SO  - Ann Neurol. 1990 Jul;28(1):50-6. doi: 10.1002/ana.410280110.