PMID- 23756397
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20131121
IS  - 1899-1505 (Electronic)
IS  - 0867-5910 (Linking)
VI  - 64
IP  - 2
DP  - 2013 Apr
TI  - The role of serotonergic 5-HT1A receptors in central cardiovascular regulation in 
      haemorrhagic shock in rats.
PG  - 219-29
AB  - The bleeding and haemorrhage is strictly related with accidents and many medical 
      procedures. In some conditions it leads to hypovolaemia and further to 
      hypovolaemic shock. Under conditions of haemorrhagic shock, heart rate and blood 
      pressure critically collapse. Reversing the sympathoinhibitory phase of 
      hypovolaemia could be crucial for clinical management of injured patients after 
      haemorrhage. Systemic administration of 5-HT1A agonists seams to produce 
      resuscitating effects. The aim of this study was to investigate the participation 
      of central serotonin and, in particular, 5-HT1A receptors in cardiovascular 
      regulation in haemorrhagic shock in rats. Intracerebroventricular (i.c.v.) 
      administration of serotonin (5-HT) increased the heart rate (HR), mean arterial 
      pressure (MAP) and implicated that all haemorrhaged animals survived for the 
      whole observation time (2 hours). Similar, although significantly more minor, 
      effects were achieved after selective 5-HT1A activation. Moreover, the i.c.v. 
      administration of selective 5-HT1A antagonist before i.c.v. 5-HT injection 
      partially inhibited 5-HT induced changes. The results of the present work 
      indicate that 5-HT plays an important role in the reversal of the haemorrhagic 
      shock in rats. These effects are at least partially dependent on activation of 
      5-HT1A receptors.
FAU - Sowa, P
AU  - Sowa P
AD  - Department of Physiology in Zabrze, Silesian Medical University in Katowice, 
      Poland. paw.sowa@gmail.com
FAU - Adamczyk-Sowa, M
AU  - Adamczyk-Sowa M
FAU - Zwirska-Korczala, K
AU  - Zwirska-Korczala K
FAU - Namyslowski, G
AU  - Namyslowski G
FAU - Misiolek, M
AU  - Misiolek M
FAU - Pierzchala, K
AU  - Pierzchala K
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Piperazines)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 115338-32-4 (1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine)
RN  - 333DO1RDJY (Serotonin)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Heart Rate/drug effects
MH  - Male
MH  - Piperazines/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Serotonin, 5-HT1A/*physiology
MH  - Serotonin/*pharmacology
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Shock, Hemorrhagic/*physiopathology
EDAT- 2013/06/13 06:00
MHDA- 2013/11/20 06:00
CRDT- 2013/06/13 06:00
PHST- 2013/01/06 00:00 [received]
PHST- 2013/04/22 00:00 [accepted]
PHST- 2013/06/13 06:00 [entrez]
PHST- 2013/06/13 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
PST - ppublish
SO  - J Physiol Pharmacol. 2013 Apr;64(2):219-29.