PMID- 23756666
OWN - NLM
STAT- MEDLINE
DCOM- 20131127
LR  - 20201209
IS  - 2233-6869 (Electronic)
IS  - 1598-9992 (Linking)
VI  - 61
IP  - 5
DP  - 2013 May
TI  - [Clarithromycin-resistant Helicobacter pylori associated with 23S rRNA point 
      mutations in Jeju Island].
PG  - 252-8
AB  - BACKGROUND/AIMS: The point mutations in 23S rRNA gene accounts for the majority 
      of the clarithromycin resistance of Helicobacter pylori. This study aimed to 
      investigate the association between the clarithromycin-resistance of H. pylori 
      and the failure of primary H. pylori eradication therapy in Jeju Island. METHODS: 
      Between April 2011 and October 2012, 6,937 patients underwent endoscopy, and H. 
      pylori infection was evaluated in 2,287 patients (33.0%). Total of 110 patients 
      with H. pylori infection were treated with proton pump inhibitor (PPI)-based 
      triple therapy. The result of eradication was evaluated with urea breath test, 
      histology and PCR which were conducted 4 weeks from the last dose of medicine. 
      RESULTS: The patients who had point mutations were 33 (26.0%). A2142G and A2143G 
      mutations were observed in 10 patients (7.9%) and 23 patients (18.1%). Among 110 
      patients treated with PPI-based triple therapy, the success rate of the 
      eradication therapy was 52.7% (58/110) and 70.7% (58/82) by intention-to-treat 
      and per-protocol analysis, respectively. Fifteen of the 24 patients who failed 
      the eradication therapy showed point mutations; 1 patient (4.2%) showed A2142G 
      mutation and 14 patients (58.3%) showed A2143G mutation. Patients with A2143G 
      mutation H. pylori showed higher failure rate of 87.5%. Patients with A2142G 
      mutation H. pylori showed similar failure rate compared to those of the patients 
      with wild type H. pylori. CONCLUSIONS: In Jeju Island, the frequency of 23S rRNA 
      point mutations is similar (26.0%) with other regions of Korea (15.8-31.3%). 
      A2143G mutation is associated with the failure of H. pylori eradication.
FAU - Kim, Taeyun
AU  - Kim T
AD  - Department of Internal Medicine, Jeju National University School of Medicine, 
      National Biobank of Korea, Jeju National University Hospital, Jeju, Korea.
FAU - Song, Hyun Joo
AU  - Song HJ
FAU - Shin, Sun Young
AU  - Shin SY
FAU - Kim, Jo-Heon
AU  - Kim JH
FAU - Na, Soo-Young
AU  - Na SY
FAU - Boo, Sun-Jin
AU  - Boo SJ
FAU - Choi, Eun Kwang
AU  - Choi EK
FAU - Cho, Yoo-Kyung
AU  - Cho YK
FAU - Kim, Heung Up
AU  - Kim HU
FAU - Song, Byung-Cheol
AU  - Song BC
LA  - kor
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (DNA, Bacterial)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (RNA, Ribosomal, 23S)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Clarithromycin/*therapeutic use
MH  - DNA, Bacterial/analysis
MH  - Drug Resistance, Bacterial
MH  - Female
MH  - Gastroscopy
MH  - Helicobacter Infections/*drug therapy
MH  - Helicobacter pylori/drug effects/*genetics
MH  - Humans
MH  - Islands
MH  - Male
MH  - Middle Aged
MH  - Point Mutation
MH  - Polymerase Chain Reaction
MH  - Proton Pump Inhibitors/therapeutic use
MH  - RNA, Ribosomal, 23S/*genetics
MH  - Republic of Korea
MH  - Young Adult
EDAT- 2013/06/13 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/06/13 06:00
PHST- 2013/06/13 06:00 [entrez]
PHST- 2013/06/13 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 201305213 [pii]
AID - 10.4166/kjg.2013.61.5.252 [doi]
PST - ppublish
SO  - Korean J Gastroenterol. 2013 May;61(5):252-8. doi: 10.4166/kjg.2013.61.5.252.